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ecg in anesthetized mice

The mouse is an excellent model for the study of physiological processes, especially since genetically modified strains have become available. ecg is one of the parameters commonly measured during phenotyping of genetically modified strains.

emka TECHNOLOGIES provides hardware for the acquisition of ecg and necessary software for these applications. There are two types of setups:

• a "hardwire" setup, in which components of the acquisition chain are wired together.
• a telemetry setup, in which radio transmission is used in part of the acquisition chain.

Components of each are described below. In both cases, the signal is acquired noninvasively via electrodes on the skin, and the mouse must therefore be anesthetized.

 

in a hardwire setup:

Each electrode is connected to an amplifier module. There is one amplifier module for each mouse, and each module contains the required number of channels. For example, a 4-channel module is required to acquire 6-lead ecg.

 

Amplifier modules are housed in a mainframe, which is connected to an interface box, from where a single cable carries all signals to the acquisition card of the computer.

 

in a telemetry setup:

An ecg cable containing the required number of electrode wires (for example, 3 for 6-lead ecg) is connected from each subject to the emkaPACK. Each emkaPACK is associated with a specific receiver module. For 6-lead ecg, a 4-channel module is required.

 

Receiver modules are housed in a mainframe, which is connected to an interface box, from where a single cable carries all signals to the acquisition card of the computer.

 

in both cases:

Data acquisition and real-time analysis can be done with iox software. The ecg analyzer available with ecg performs basic heart rate analysis.

 

For full and powerful ecg analysis based on shape recognition techniques, use ecgAUTO to analyze your iox data files.

Also required is a device to maintain body temperature, such as a thermal pad (not supplied).

Please contact us for further information about measuring ecg in anesthetized mice.