cardiovascular applications
action potentialinputs:
action potential
stimulation pulse (optional)
parameters:
• resting membrane potential
• conduction time
• maximum rate of depolarization
• position of max dV/dt
• action potential overshoot
• action potential amplitude
• plateau voltage
• action potential duration at 5 user-defined percentages
• rate (beats/minute)
• effective refractory period
• recovery time
blood pressure
parameters:
• systolic pressure
• diastolic pressure
• amplitude
• mean pressure
• heart rate
blood flow
inputs:
• blood flow
• blood pressure (optional)
parameters:
• systolic & diastolic flows
• mean flow
• stroke volume
• cardiac output
• heart rate
• mean blood pressure
• total peripheral resistance
left ventricular pressure (LVP) parameters:
• peak systolic pressure
• start- & end- diastolic pressures
• developed pressure
• mean systolic & diastolic pressures
• systolic ejection period
• diastolic filling period
• contraction time
• relaxation time
• maximum& Minimum derivatives
• contractility index
• maximum velocity at P0
• heart rate
• relaxation constant Tau (3 methods)
ECG
parameters:
• R amplitude
• RR interval
• QRS interval
• isoelectric line
• S average
• S area
Heart rate
segment length/wall thickness
parameters:
• maximum & minimum lengths
• mean length
• maximum & minimum derivatives
• frequency
• end-diastolic & systolic lengths
• fractional shortening & thickening
real-time pressure volume/distance loops
parameters:
Same as LVP (above) plus:
• maximum & minimum volumes
• end-systolic and diastolic -volumes
• stroke volume
• cardiac output
• ejection fraction
• stroke work (SW)
• preload recruitable SW
• end-diastolic P/V (or P/D) relation
• end-systolic P/V (or P/D) relation
• effective arterial elastance Ea(t)
• Dpdtmax/Ed
examples of use
blood pressure analyzer
Radovits et al (2007) The peroxynitrite decomposition catalyst FP15 improves
ageing-associated cardiac and vascular dysfunction. Mechanisms of Ageing and Development 128:173–181
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ecg analyzerKijtawornrat A, Roche BM, Hamlin RL (2008). A Canine Model of Sustained Atrial Fibrillation Induced by Rapid Atrial Pacing and Phenylephrine. Comp Med. 58(5): 490–493.
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