literature

Read one of the many publications in which emka TECHNOLOGIES is cited.

For literature requests please contact: sales@emka.fr

application : cardiovascular

H. Mongue-Din,1,2 A. Salmon,1,2 M. Y. Fiszman,1,2 and Y. Fromes 1,2,3, Periodic variation in R-R intervals and cardiovascular autonomic regulation in young adult Syrian hamsters (1.11 Mo), Am J Physiol Regul Integr Comp Physiol 296: R610-R617, 2009. First published December 24, 2008; doi:10.1152/ajpregu.90376.2008 0363-6119/09, 1 Institut de Myologie-Institut National de la Sante et de la Recherche Medicale U582; 2 Universite Pierre et Marie Curie-Faculte de Medecine; 3 Groupe Hospitalier Paris Saint Joseph, Department of Cardiac Surgery, Perfusion Unit, Paris, France, 2009

Annie Delaunois a, Paul Dedoncker a, Etienne Hanon b, Michel Guyaux a,⁎, Repeated assessment of cardiovascular and respiratory functions using combined telemetry and whole-body plethysmography in the rat (1.8 Mo), Journal of Pharmacological and Toxicological Methods 60 (2009) 117-129, a Department of Non Clinical Development, Non Clinical Safety Pharmacology Group, UCB Pharma SA, Belgium b Department of CNS Research, Biological Data Analysis, UCB Pharma SA, Belgium, 2009

Jacques M. Lignon1, Zoë Bichler2, Bruno Hivert1, François E. Gannier1, Pierre Cosnay1, José A. del Rio2, Danièle Migliore-Samour3 and Claire O. Malécot1, Altered heart rate control in transgenic mice carrying the KCNJ6 gene of the human chromosome 21 (653.1 Ko), Physiol. Genomics 33: 230-239, 2008. First published February 26, 2008; doi:10.1152/physiolgenomics.00143.2007 1094-8341/08, 1 Centre National de la Recherche Scientifique Unité Mixte de Recherche 6542, Physiologie des Cellules Cardiaques et Vasculaires, Université François-Rabelais, Parc Grandmont, Tours, France - 2 Department of Cell Biology, Institute for Research in Biomedicine, University of Barcelona, Barcelona, and CIBERNED, Spain - 3 Centre National de la Recherche Scientifique Institut de Trangénose, Orléans-La Source, France, 2008

Cendrine Cabou,1,2,3 Gerard Campistron,1,2,3 Nicolas Marsollier,4 Corinne Leloup,2,5 Celine Cruciani-Guglielmacci,4 Luc Pe´nicaud,2,5 Daniel J. Drucker,6 Christophe Magnan,4 and Remy Burcelin1,2, Brain glucagon-like peptide-1 regulates arterial blood flow, heart rate, and insulin sensitivity. (738.09 Ko), American Diabetes Association - DIABETES, VOL. 57, OCTOBER 2008, 1Institut National de la Sante´ et de la Recherche Me´ dicale (INSERM), U858, Institute of Molecular Medicine Rangueil, Toulouse, France; the 2Universite´ Toulouse III Paul-Sabatier, IFR31, Toulouse, France; the 3Faculte´ des Sciences Pharmaceutiques, Toulouse, France; the 4Universite´ Paris 7, UMR CNRS 7059, Paris, France; 5UMR UPS-CNRS 5241, Toulouse, France; and the 6Banting and Best Diabetes Centre, Samuel Lunenfeld Research Institute, Mt. Sinai Hospital, University of Toronto, Toronto, Ontario, Canada., 2008

Robert L. Hamlin, Anusak Kitjtawornrat, Brian M. Roche, Jennifer L. Lolly, A comprehensive assessment of drug effects on cardiovascular function, including cardiac output and regional distribution of cardiac output, in the anesthetized beagle dog (213.07 Ko), Journal of Pharmacological and Toxicological Methods, Volume 58, Issue 2, September-October 2008, Page 159, The Ohio State University/ QTest Labs, LLC., 2007

Cendrine Cabou 1, Patrice D. Cani 1, Gérard Campistron 1, Claude Knauf 1, Caroline Mathieu 2, Claudio Sartori 2, Jacques Amar 3 , Urs Scherrer 2, and Rémy Burcelin 1, Central insulin regulates heart rate and arterial blood flow: an endothelial nitric oxide synthase-dependent mechanism altered during diabetes (270.31 Ko), Diabetes - A journal of the american diabetes association. , 1 Inserm U858, Institute of Molecular Medicine I²MR, Research team « Functional Genomic of Metabolic Diseases », IFR31, CHU Rangueil, BP 84225, 31432 Toulouse Cedex 4, France. 2 CHUV Lausanne, Switzerland. 3 Inserm U558, Toulouse, France., 2007

Alexandre SARRE 1 PhD, Philippe MAURY 1,3 MD, Pavel KUCERA 1 MD, Lukas KAPPENBERGER 2 MD and Eric RADDATZ 1 PhD, Arrhythmogenesis in the developing heart during anoxia-reoxygenation and hypothermia-rewarming: an in vitro model. (917.31 Ko), The Journal of Cardiovascular Electrophysiology, Department of Physiology, Faculty of Biology and Medicine, 2)Division of Cardiology, Hospital University, Lausanne, Switzerland, and 3)Federation of Cardiology, Hospital University Rangueil, Toulouse, France, 2006

Thomas Vormberge, Michael Hoffmann, Herbert Himmel, Safety pharmacology assessment of drug-induced QT-prolongation in dogs with reduced repolarization reserve (492.22 Ko), Journal of Pharmacological and Toxicological Methods 54 (2006) 130–140, BHC-PH-GDD-Toxicology, Department Clinical Pathology and Safety Studies, Bayer HealthCare AG, Aprather Weg 18a, D-42096 Wuppertal, Germany, 2006

REBOUL, CYRIL 1,2; TANGUY, STEPHANE 2; DAUZAT, MICHEL 1; OBERT, PHILIPPE 2, Altitude Negates the Benefits of Aerobic Training on the Vascular Adaptations in Rats., Medicine & Science in Sports & Exercise. 37(6):979-985, June 2005., Dynamique des Incohérences Cardio-Vasculaires, Faculté de Médecine de Nîmes, Montpellier; and 2Physiologie des Adaptations Cardiovasculaires à l'Exercice, Faculté des Sciences, Avignon, France, 2005

F. Kerendi1, H. Kin1, M. E. Halkos1, R. Jiang1, A. J. Zatta1, Z.–Q. Zhao1, R. A. Guyton1 and J. Vinten–Johansen, Brief renal ischemia and reperfusion applied before coronary artery reperfusion reduces myocardial infarct size via endogenous activation of adenosine receptors, Basic Research in Cardiology, Cardiothoracic Research Laboratory, Carlyle Fraser Heart Center, 550 Peachtree Street, Atlanta (GA) 30308, USA, 2005

C. Reboul,1,2 S. Tanguy,2 A. Gibault,1,2 M. Dauzat,1 and P. Obert2 , Chronic hypoxia exposure depresses aortic endothelium-dependent vasorelaxation in both sedentary and trained rats: involvement of L-arginine, J Appl Physiol 99: 1029-1035, 2005., Dynamique des Incohérences Cardio-Vasculaires, Faculté de Médecine de Nîmes, Montpellier; and 2Physiologie des Adaptations Cardiovasculaires à l'Exercice, Faculté des Sciences, Avignon, France, 2005

Constantinos Pantos, Iordanis Mourouzis, Vassiliki Malliopoulou, Ioannis Paizis, Stylianos Tzeis, Panagiotis Moraitis, Konstantinos Sfakianoudis, Dennis D. Varonos, Dennis V. Cokkinos, Dronedarone Administration Prevents Body Weight Gain and Increases Tolerance of the Heart to Ischemic Stress: A Possible Involvement of Thyroid Hormone Receptor á1, Thyroid. Jan 2005, Vol. 15, No. 1: 16-23, Department of Pharmacology, University of Athens, Athens, Greece, 2005

Colin W. Sereda, DVM1, Christopher A. Adin, DVM, Diplomate ACVS1, Pamela E. Ginn, DVM, Diplomate ACVP1, and James P. Farese, DVM, Diplomate ACVS, Evaluation of a Percutaneously Controlled Hydraulic Occluder in a Rat Model of Gradual Venous Occlusion, Veterinary Surgery - Volume 34 Page 35 - January 2005, From the Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, Gainesville, FL, 2005

Alexander Deten*, Grit Marx, Wilfried Briest, Hans Christian Volz, Heinz-Gerd Zimmer, Heart function and molecular biological parameters are comparable in young adult and aged rats after chronic myocardial infarction (343.8 Ko), Cardiovascular Research 66 (2005) 364– 373, Carl-Ludwig-Institute of Physiology, Leipzig University, Liebigstr.27, D-04103 Leipzig, Germany, 2005

Gautier, Patrick PhD; Serre, Martine PhD; Cosnier-Pucheu, Sylvie PhD; Djandjighian, Laurent VetD; Roccon, Alain; Herbert, Jean-Marc PhD; Nisato, Dino PhD, In Vivo and In Vitro Antiarrhythmic Effects of SSR149744C in Animal Models of Atrial Fibrillation and Ventricular Arrhythmias., Journal of Cardiovascular Pharmacology. 45(2):125-135, February 2005., Cardiovascular Thrombosis Department, Sanofi-Synthélabo Recherche, 34184 Montpellier Cedex 04, France, 2005

G. Mayer, M.B. Princivalle, V. Goddard, D. J. Corkill, R.M. Haigh, C.M. Yea and R.L C. Handy, Investigation of the in vitro effect of vasopressin and oxytocin in the rat and Guinea-pig uterus (220.7 Ko), British Pharmacological Society, Biology Department, Ferring Research Ltd, 2005

Jarrod D. Knudson,1 Ü. Deniz Dincer,1 Gregory M. Dick,1 Haruki Shibata,2 Rie Akahane,2 Masayuki Saito,3 and Johnathan D. Tune, Leptin resistance extends to the coronary vasculature in prediabetic dogs and provides a protective adaptation against endothelial dysfunction, Am J Physiol Heart Circ Physiol 289: H1038-H1046, 2005, Department of Physiology, Louisiana State University Health Sciences Center, New Orleans, Louisiana, 2005

Anne Royer, PhD*; Toon A.B. van Veen, PhD*; Sabrina Le Bouter, PhD; Céline Marionneau, MSc; Violaine Griol-Charhbili, MSc; Anne-Laure Léoni, DVM; Marja Steenman, PhD; Harold V.M. van Rijen, PhD; Sophie Demolombe, PhD; Catharine A. Goddard, PhD; Christine Richer, PharmD, PhD; Brigitte Escoubet, MD, PhD; Thérèse Jarry-Guichard, PhD; William H. Colledge, PhD; Daniel Gros, PhD; Jacques M.T. de Bakker, PhD; Andrew A. Grace, PhD, FRCP; Denis Escande, MD, PhD; Flavien Charpentier, PhD , Mouse Model of SCN5A-Linked Hereditary Lenegre’s Disease - Age-Related Conduction Slowing and Myocardial Fibrosis (1.3 Mo), Circulation , INSERM U533, Institut du Thorax, 2005

Michel Slama,1 Jwari Ahn,2 Marcel Peltier,1 Julien Maizel,1 Denis Chemla,3 Jasmina Varagic,2 Dinko Susic,2 Christophe Tribouilloy,1 and Edward D. Frohlich, Validation of echocardiographic and Doppler indexes of left ventricular relaxation in adult hypertensive and normotensive rats, Am J Physiol Heart Circ Physiol 289: H1131-H1136, 2005, ERI 12, UPRES 3906, INSERM Faculté de Médecine, Université Jules Verne, Amiens, France, 2005

Pu Zong, Wei Sun, Srinath Setty, Johnathan D. Tune and H. Fred Downey, Adrenergic Vasoconstrictor Tone Limits Right Coronary Blood Flow in Exercising Dogs (195.24 Ko), Experimental Biology and Medicine 229:312-322 (2004), Department of Integrative Physiology, University of North Texas Health Science Center, 3500 Camp Bowie Boulevard, Fort Worth, Texas 76107, 2004

Klaus Witte A1, Stefan Engelhardt A2, Ben J. A. Janssen A3, Martin Lohse A2, Björn Lemmer A, Circadian and Short-Term Regulation of Blood Pressure and Heart Rate in Transgenic Mice with Cardiac Overexpression of The ß 1-Adrenoceptor, Chronobiology International, Institute of Pharmacology and Toxicology, University of Heidelberg, Mannheim, Germany, 2004

Jérémy Fauconnier,1 Alain Lacampagne,1 Jean-Michel Rauzier,1 Pierre Fontanaud,2 Jean-Marc Frapier,1 Ole M. Sejersted,3 Guy Vassort,1 and Sylvain Richard1 , Frequency-dependent and proarrhythmogenic effects of FK-506 in rat ventricular cells, Am J Physiol Heart Circ Physiol 288: H778-H786, 2005, Physiopathologie Cardiovasculaire, Institut National de la Santé et de la Recherche Médicale U-637, Université Montpellier 1, and 2Unité Propre de Recherche 9055, Centre National de la Recherche Scientifique, Montpellier, France; and 3Institute for Experimental Medical Research, University of Oslo and Ullevaal University Hospital, Oslo, Norway, 2004

Anne-Marie Bétat, Estelle Louis, Guillaume Froget, Pierre Lainée and Roy Forster., Influence of hypokalemia on drug-induced qt prolongation in the conscious telemetered guinea pig. (1.31 Mo), Safety Pharmacology Society Meeting, CIT, Evreux, France, 2004

P. Nivoit A1, A. Chevrier A1, M. Lagarde A2, C. Renaudin A1, N. Wiernsperger A1, Noninvasive Orthogonal Polarization Spectral Imaging as Applied to Microvascular Studies in Mice, Experimental Diabesity Research volume 5, Number 3 / July-September 2004, Diabetic Microangiopathy Research Unit, Villeurbanne Cedex, France, 2004

Martine Clozel; Christoph Binkert; Magdalena Birker-Robaczewska; Céline Boukhadra; Shuang-Shuang Ding; Walter Fischli; Patrick Hess; Boris Mathys; Keith Morrison; Celia Müller; Claus Müller; Oliver Nayler; Changbin Qiu; Markus Rey; Michael W. Scherz; Jörg Velker; Thomas Weller; Jian-Fei Xi; Patrick Ziltener, Pharmacology of the Urotensin-II receptor Antagonist Palosuran (ACT-058362;1 {2 (4 benzyl 4 hydroxy piperidin 1 yl) ethyl} 3 (2 methyl quinolin 4 yl) urea Sulfate Salt): First Demonstration of a Pathophysiological Role of the Urotensin System (155.04 Ko), The Journal of Pharmacology and Experimental Therapeutics Fast Forward, May 14, 2004; 10.1124, Actelion Pharmaceuticals Ltd Allschwil, 2004

Yiqiang Zhou,1 Hsin-Hsin Chang,1 Juan Du,1 Cong-Yi Wang,2 Zheng Dong,3 and Mong-Heng Wang1 , Renal epoxyeicosatrienoic acid synthesis during pregnancy (827.63 Ko), AJP - Renal 288:221-226, 2005., Department of Physiology, Medical College of Georgia, Augusta, Georgia 30912, 2004

Obst, Michael a; Gross, Volkmar a; Luft, Friedrich C a,b, Systemic hemodynamics in non-anesthetized l-NAME- and DOCA-salt-treated mice., Journal of Hypertension. 22(10):1889-1894, October 2004., MAX-DELBRÜCK-CENTRUM-FÜR-MOLEKULARE-MEDIZIN, Berlin, Germany, 2004

Sébastien Bonnet; Eric Dumas-de-La-Roque; Hugues Bégueret; Roger Marthan; Michael Fayon; Pierre Dos Santos; Jean-Pierre Savineau; Etienne-Emile Baulieu, Dehydroepiandrosterone (DHEA) prevents and reverses chronic hypoxic pulmonary hypertension , PNAS-August 5, 2003; vol 100, n°16, 9488-9493, EMI Université de Bordeaux II; INSERM U441 Pessac; INSERM U488 Hôpital Kremlin-Bicêtre, 2003

Jean-Paul Morin; Stéphane Loriot; Jean-Paul Henry; Christian Thuillez, Impact des émissions de moteurs à combustion interne sur l'ECG de rats sains et insuffisants cardiaques vigiles, non contraints, exposés par inhalation , , Inserm Rouen, 2003

Fadi Jamal; Cyrille Bergerot; Laurent Argaud; Joseph Loufouat; Michel Ovize, Longitudinal strain quantitates regional right ventricular contractile function , Am J Physiol Heart Circ Physiol 285: H2842-H2847, 2003, Université Claude Bernard Lyon I, 2003

Axel Gödecke; Andre Molojavyi; Jacqueline Heger; Ulrich Flögel; Zhaoping Ding; Christoph Jacoby; Jürgen Schrader, Myoglobin Protects the Heart from Inducible Niric-oxide Synthase (iNOS)-mediated Nitrosative Stress (363.31 Ko), The Journal of Biological Chemistry vol 278, n°24, june137, 2003, 21761-21766, Heinrich-Heine-Universität of Düsseldorf, 2003

C Pantos; V Malliopoulou; I Mourouzis; K Sfakianoudis; S Tzeis; P Doumba; C Xinaris; A D Cokkinos; H Carageorgiou; D D Varonos; D V Cokkinos, Propylthiouracil-induced hypothyroidism is associated with increased tolerance of the isolated rat heart to ischaemia-reperfusion (331.79 Ko), Journal of Endocrinology (2003) 178, 427-435, University of Athens; Onassis cardiac Surgery Center of Athens, 2003

Micheletti ; Mattera ; Rocchetti;Schiavone; Loi; Zaza; Gagnol ;De Munari; Melloni ; Carminati; Bianchi; Ferrari, Pharmacological Profile of the novel inotropic agent (E,Z)-3-((2-Aminoethoxy)imino)androstane)-6,17-dione hydrochloride (PST2744) (177.27 Ko), The journal of pharmacology and experimental therapeutics JPET 303:592-600, 2002, Sigma-Tau Milan, 2002

Versigny A., Goubern M., Provost D., Camborde F., Caussade F., Suitability of canine models for revealing the ability of drug candidates to prolong QT interval (105.88 Ko), XIVth World Congress of Pharmacology - July 7-12, 2002 - San Francisco, CA (USA), Cerep, 2002

Jean-Noël Trochu; Véronique Leblais; Yahann Rautureau; Fabrizio Bévérelli; Hervé Le Marec; Alain Berdeaux; Chantal Gauthier , Beta 3-adrenoceptor stimulation induces vasorelaxation mediated essentially by endothelium-derived nitric oxide in rat thoracic aorta, Br. J; Pharmacol.(1999), 128: 69-76 , CHU de Nantes; Fac Med Kremlin Bicêtre; Nantes U; Nantes Hötel Dieu , 1999

Louis Puybasset; Marie-Luce Bea; Bijan Ghaleh; Jean-Francçois Giudicelli; Alain Berdeaux, Coronary and Systemic Hemodynamic Effects of Sustained Inhibition of Nitric Oxide Synthesis in Conscious Dogs (237.41 Ko), Circulation Research. 1996; 79: 343-357, Faculté de Médecinde Paris-Sud, Le Kremlin-Bicêtre, 1999

application : ecg

top of page

Mihail G. Chelu,1,2 Satyam Sarma,1,3 Subeena Sood,1 Sufen Wang,4,5 Ralph J. van Oort,1 Darlene G. Skapura,1 Na Li,1 Marco Santonastasi,1 Frank Ulrich Müller,6 Wilhelm Schmitz,6 Ulrich Schotten,7 Mark E. Anderson,8 Miguel Valderrabano,4,5 Dobromir Dobrev,9 and Xander H.T. Wehrens1,3, Calmodulin kinase II–mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice (1.13 Mo), The Journal of Clinical Investigation, Volume 119, Number 7, 1 Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Texas, USA. - 2 Department of Internal Medicine, University of Texas Health Science Center, Houston, Texas, USA. - 3 Department of Medicine, Division of Cardiology, Baylor College of Medicine, Houston, Texas, USA. - 4 Department of Cardiology, The Methodist Hospital, Houston, Texas, USA. - 5 Division of Cardiology, Weill Medical College of Cornell University, New York, New York, USA. - 6 Institute of Pharmacology and Toxicology, University of Münster, Münster, Germany. - 7 Department of Physiology, Maastricht University, Maastricht, The Netherlands. - 8 Department of Internal Medicine, Division of Cardiovascular Medicine, and Department of Molecular Physiology and Biophysics, University of Iowa - Carver College of Medicine, Iowa City, Iowa, USA. - 9 Department of Pharmacology and Toxicology, Dresden University of Technology, Dresden, Germany., 2009

Guey-Shin Wang,1 Muge N. Kuyumcu-Martinez,1 Satyam Sarma,2,3 Nitin Mathur,2,3 Xander H.T. Wehrens,2,3 and Thomas A. Cooper1,4, PKC inhibition ameliorates the cardiac phenotype in a mouse model of myotonic dystrophy type 1 (2.23 Mo), The Journal of Clinical Investigation, Volume 119, Number 12, 1 Department of Pathology, 2 Department of Molecular Physiology and Biophysics, 3 Department of Medicine (Cardiology), and 4 Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, USA., 2009

Haisong Ju, Xuejun Wu, Robert Coatney, Jason Payseur, Lynne King, Jon Renninger, and Dennis Murphy, An Improved Method for ECG Recording in Conscious Dogs and Monkeys: Pericardial Lead Placement (907.34 Ko), SPS Scientific Poster Presentation, Safety Pharmacology, GlaxoSmithKline, King of Prussia, PA, 2008

Y. Panyasing1,2, A. Kijtawornrat1, C. Del Rio1, L. Snedden1, T. Mongkolmaneepol1, J. Schmidt1, T. Brown1, R. Hamlin1,2, Analysis of Dynamic Restitution of ECG Parameters in the Rabbit Langendorff Heart Exposed to Drugs That Lengthen or Abbreviate QT (108.52 Ko), SPS Scientific Poster Presentation, 1 QTest Labs, LLC, Columbus, OH - 2 The Ohio State University, Columbus, OH, 2008

Ray Chui, Abigail Fosdick, Ra’Shun Conner and Hugo M. Vargas, Assessment of Two External Telemetry Systems in Implanted Beagle Dogs, SPS Scientific Poster Presentation, Investigative Safety Pharmacology, Dept. of Investigative Toxicology, Amgen Inc., Thousand Oaks, CA, 2008

Katy Rivard 1,2, Pierre Paradis 3, Mona Nemer 3, and Ce line Fiset 1,2,*, Cardiac-specific overexpression of the human type 1 angiotensin II receptor causes delayed repolarization (840.97 Ko), Cardiovascular Research (2008) 78, 53-62, 1 Research Centre, Montreal Heart Institute, 5000 Rue Belanger, Montreal, QC, Canada H1T 1C8; 2 Universite de Montreal, Faculty of Pharmacy, Montreal, QC, Canada; and 3 Institut de Recherche Clinique de Montreal, Montreal, QC, Canada, 2008

del Rio CL1,2, Snedden L1, Ueyama Y2, Panyasing Y1,2, Zwijnenberg R3, Kijtawornrat A1,2, Hamlin RL1,2, Muir WW1,2, Concentration-Dependent Changes in ECG-Derived Indices of Repolarization Triggered by Isoflurane: A Study in Telemetered Beagle Dogs (453.7 Ko), SPS Scientific Posters, 1: QTest Labs, 2: The Ohio State University - Columbus, OH (USA) and 3: Fort Dodge Animal Health - Princeton, NJ (USA), 2008

Emily R. Nolan a,⁎, Marc B. Bailie b, N.B. Olivier a, Effect of autonomic blockade on ventricular repolarization shortening: Response to behavioral stimulus in paced dogs (232.09 Ko), a Cardiovascular Research Lab, College of Veterinary Medicine, Michigan State University, East Lansing, MI 48824, United States - b Department of Pharmacology and Toxicology, B-440 Life Sciences Building, Michigan State University, East Lansing, MI, United States, Autonomic Neuroscience: Basic and Clinical 140 (2008) 66–71, 2008

Katy Rivard,1,2 Veronique Trepanier-Boulay,1,2 Hansjorg Rindt,1 and Celine Fiset1,2, Electrical remodeling in a transgenic mouse model of α1B-adrenergic receptor overexpression (4.58 Mo), Am J Physiol Heart Circ Physiol 296: H704-H718, 2009., 1 Research Center, Montreal Heart Institute, and 2 Faculty of Pharmacy, Universite de Montreal, Montreal, Quebec, Canada, 2008

Haisong Ju, Xuejun Wu, Jason Payseur, Jon Renninger, Dennis Murphy, Evaluation of Test Article-Related Ventricular Premature Complexes in Conscious Telemetered Dogs. (805.57 Ko), SPS Scientific Poster Presentation, Safety Pharmacology, GlaxoSmithKline, King of Prussia, PA, 2008

Aimen K. Farraj,1 Najwa Haykal-Coates,1 Darrell W. Winsett,1 Mehdi S. Hazari,1 Alex P. Carll,2 William H. Rowan, III,3 Allen D. Ledbetter,1 Wayne E. Cascio,4 and Daniel L. Costa5, Increased non-conducted P-wave arrhythmias after a single oil fly ash inhalation exposure in hypertensive rats. (408.84 Ko), Environ Health Perspect. 2009 May; 117(5): 709–715., 1Experimental Toxicology Division, National Health and Environmental Effects Research Laboratory, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA; 2Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA; 3ITT Corporation, Advanced Engineering and Sciences, Alexandria, Virginia, USA; 4Brody School of Medicine, East Carolina University, Greenville, North Carolina, USA; 5Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, North Carolina, USA, 2008

Cécile Fligny,* Yves Fromes,† Philippe Bonnin,§ Michèle Darmon,‡ Elisa Bayard,* Jean-Marie Launay,|| Francine Côté,* Jacques Mallet,*,1 and Guilan Vodjdani*,1, Maternal serotonin influences cardiac function in adult offspring. (588.95 Ko), The FASEB Journal, Vol. 22 July 2008, *Unité Mixte de Recherche 7091 Centre National de la Recherche Scientifique/Université Pierre et Marie Curie, Laboratoire de Génétique Moléculaire de la Neurotransmission et des Processus Neurodégénératifs (LGN), †Institut de Myologie, U582 Institut National de la Santé et de la Recherche Médicale, and ‡Unité Mixte de Recherche 677 Institut National de la Santé et de la Recherche Médicale/ Université Pierre et Marie Curie, Laboratoire de Neuropsychopharmacologie, Hôpital de la Pitié-Salpêtrière, Paris, France; and § Centre de Recherche Cardiovasculaire, Physiologic Explorations Fonctionnelles, U689 Institut National de la Santé et de la Recherche Médicale, Université Denis Diderot, and ||Service de Biochimie, Hôpital Lariboisière, APHP, Paris, France, 2008

P Hess, M Rey, D Wanner, B Steiner and M Clozel, Measurements of blood pressure and electrocardiogram in conscious freely moving guineapigs a model for screening QT interval prolongation effects (327.49 Ko), Laboratory Animals (2007) 41, 470–480 , Pharmacology and Preclinical Development, Actelion Pharmaceuticals Ltd, 2007

H. Mongue-Din, A. Salmon, M. Y. Fiszman, Y. Fromes , Non-invasive restrained ecg recording in conscious small rodents a new tool for cardiac electrical activity investigation. (279.74 Ko), European Journal of Physiology - 454:165–171 , Institut de Myologie—INSERM U582, Groupe Hospitalier Pitié-Salpêtrière., 2007

Paulus Kirchhof, MD; Larissa Fabritz, MD; Melanie Zwiener, VetD; Henning Witt, PhD; Michael Schäfers, MD; Stephan Zellerhoff, MD; Matthias Paul, MD; Timur Athai, BS; Karl-Heinz Hiller, PhD; Hideo A. Baba, MD; Günter Breithardt, MD; Patricia Ruiz, PhD; Thomas Wichter, MD; Bodo Levkau, MD, Age- and Training-Dependent Development of Arrhythmogenic Right Ventricular Cardiomyopathy in Heterozygous Plakoglobin-Deficient Mice (589.55 Ko), Circulation. 2006;114:1799-1806, Department of Cardiology and Angiology, Hospital of the University of Muenster, 2006

Membrez M, Hummler E, Beermann F, Haefliger JA, Savioz R, Pedrazzini T, Thorens B., GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function. (722.08 Ko), Molecular and Cellular Biology, June 2006, p. 4268-4276, Vol. 26, No. 11, Institute of Physiology, University of Lausanne, Center for Integrative Genomics, Génopode Building, CH-1015 Lausanne, Switzerland., 2006

Emily R. Nolana,T, Meihua Rose Fenga, Jeffrey R. Koupa, Jing Liua, Daniel Turlucka, Yiqun Zhanga, Jerome B. Paulissena, N. Bari Olivierb, Teresa Millera, Marc B. Bailiea, A novel predictive pharmacokinetic/pharmacodynamic model of repolarization prolongation derived from the effects of terfenadine, cisapride and E-4031 in the conscious chronic av node—ablated, His bundle-paced dog (209.81 Ko), Journal of Pharmacological and Toxicological Methods 53 (2006) 1 –10, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, United States - Michigan State University College of Veterinary Medicine, East Lansing, MI, United States, 2005

Antoine Ouvrard-Pascaud, PhD*; Yannis Sainte-Marie*; Jean-Pierre Bénitah, PhD; Romain Perrier, MS; Christelle Soukaseum; Aurelie Nguyen Dinh Cat, MS; Anne Royer, MS; Khai Le Quang, MS; Flavien Charpentier, PhD; Sophie Demolombe, PhD; Fatima Mechta-Grigoriou, PhD; Ahmed T. Beggah, PhD; Pierre Maison-Blanche, MD; Marie-Edith Oblin, PhD; Claude Delcayre, PhD; Glenn I. Fishman, MD; Nicolette Farman, MD, PhD; Brigitte Escoubet, MD, PhD; Frederic Jaisser, MD, PhD, Conditional Mineralocorticoid Receptor Expression in the Heart Leads to Life-Threatening Arrhythmias, Circulation. 2005;111:3025-3033, INSERM U533, Medical School, Nantes, France, 2005

Jean-Christophe Peter, Jean Tugler*, Pierre Eftekhari*, Damien Maurice*, Johan Hoebeke and Jean-Christophe Roegel, Effects on heart rate of an anti-M2 acetylcholine receptor immune response in mice, The FASEB Journal. 2005;19:943-949, C.N.R.S, UPR 9021, IBMC, Laboratory of Immunological and Therapeutical Chemistry, Strasbourg; and Forenap Therapeutic Discovery, Institute of Pharmacology, School of Medicine, Strasbourg, France, 2005

Anne Royer, PhD*; Toon A.B. van Veen, PhD*; Sabrina Le Bouter, PhD; Céline Marionneau, MSc; Violaine Griol-Charhbili, MSc; Anne-Laure Léoni, DVM; Marja Steenman, PhD; Harold V.M. van Rijen, PhD; Sophie Demolombe, PhD; Catharine A. Goddard, PhD; Christine Richer, PharmD, PhD; Brigitte Escoubet, MD, PhD; Thérèse Jarry-Guichard, PhD; William H. Colledge, PhD; Daniel Gros, PhD; Jacques M.T. de Bakker, PhD; Andrew A. Grace, PhD, FRCP; Denis Escande, MD, PhD; Flavien Charpentier, PhD, Mouse Model of SCN5A-Linked Hereditary Lenègre’s Disease, Circulation. 2005;111:1738-1746., INSERM U533, Institut du Thorax, Faculté de Médecine, 1 rue G. Veil, 44035 Nantes cedex, France, 2005

Qing Wang; Andrea A. Domenighetti; Thierry Pedrazzini; Michel Burnier , Potassium supplementation reduces cardiac and renal hypertrophy independent of blood pressure in DOCA/salt mice. (381.3 Ko), Hypertension. 2005;46:547, From the Division of Nephrology (Q.W., M.B.) and the Department of Medicine (A.A.D., T.P.), University Hospital, Lausanne, Switzerland. Correspondence to Prof Michel Burnier, Division of Nephrology, CHUV, rue du Bugnon 17, CH-1011 Lausanne, Switzerland, 2005

Jean-Christophe Peter, Gerd Wallukat, Jean Tugler||, Damien Maurice||, Jean-Christophe Roegel||, Jean-Paul Briand, and Johan Hoebeke, Modulation of the M2 Muscarinic Acetylcholine Receptor Activity with Monoclonal Anti-M2 Receptor Antibody Fragments (725.75 Ko), J. Biol. Chem., Vol. 279, Issue 53, 55697-55706, December 31, 2004, CNRS, Unité Propre de Recherche 9021, Institut de Biologie Moléculaire et Cellulaire, Laboratory of Therapeutical Chemistry and Immunology, F-67084 Strasbourg, France, 2004

ROB SANDERS, MARC BAILIE, N. BARI OLIVIER, Stability of Ventricular Repolarization in Conscious Dogs with Chronic Atrioventricular Dissociation and His-Bundle Pacing, Pacing and Clinical Electrophysiology Volume 27 Page 1475 - November 2004, Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, 2004

Kamil Nahas, Philippe Baneux, David Detweiler, Electrocardiographic monitoring in the Gottingen minipig (1.29 Mo), Comparative Medicine, Vol 52, No3, June 2002, Pages 256-264, American Association for Laboratory Animal Science, 2002

application : eeg

top of page

Gaspard Montandon 1,2, Richard L.Horner1, Richard Kinkead 2 and Aida Bairam 2, Caffeine in the neonatal period induces long-lasting changes in sleep and breathing in adult rats (627.84 Ko), J Physiol 587.22 (2009) pp 5493-5507, 1 Departments of Medicine and Physiology, Faculty of Medicine, University of Toronto, Ontario, M5s 1A8, Canada - 2 Department of Pediatrics, Faculty of Medicine, Hopital St-Franccois d'Assise, Universite de Laval, Quebec, Canada, 2009

application : hrv

top of page

Thireau J, Zhang BL, Poisson D, Babuty D., Heart rate variability in mice: a theoretical and practical guide (481.33 Ko), Exp Physiol 93:83–94, Heart rate variability, 2007

application : isolated organs

top of page

Dragan Pavlovic,* Helge Frieling,*§ Taras Usichenko,* Vladimir Nedeljkov,† Thais Nafissi,‡ Christian Lehmann,* Michel Aubier‡ and Michael Wendt*, s-carboxymethylcysteine inhibits carbachol-induced constriction of epithelium-denuded rat and human airway preparations (223.68 Ko), Clinical and Experimental Pharmacology and Physiology, *Department of Anaesthesiology and Intensive Care Medicine, Ernst-Moritz-Arndt University, Greifswald, Germany, †Institute for Pathophysiology, Medical Faculty, Belgrade University, Belgrade, Serbia and ‡INSERM U408, Faculte Xavier-Bichat, Universite Paris 7, Paris, France, 2008

XU Tian －ying， MIAO Chao －yu , 新化合物 SIPI5052 对离体血管收缩功能的影响 - Effect of SIPI5052， a new chemical entity， on the contraction of isolated arteries (789.52 Ko), 中华中西医杂志　Chinese Journal of Traditional and Waestern Medicine 200C 年第７卷　第 18 期, Second Military Medical University， Shanghai 200433， China【关键词】　哌嗪类；主动脉；肠系膜动脉；收缩反应；钙通道；抗脑缺血　　【中图分类号】　R-33　　　　【文献标识码】　A　　　　【文章编号】　1606 －8106（2006）18 －1636 －03, 2006

Martine Clozel*,1, Patrick Hess*, Markus Rey*, Marc Iglarz*, Christoph Binkert* and Changbin Qiu*,**, Bosentan, sildenafil, and their combination in the monocrotaline model of pulmonary hypertension in rats. (97.68 Ko), Experimental Biology and Medicine 231:967-973 (2006), * Actelion Pharmaceuticals Ltd, CH-4123 Allschwil, Switzerland; and **Department of Pharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China, 2006

Desjardins, Fanny *+; Aubin, Marie-Claude *+; Carrier, Michel *++; Perrault, Louis P , Decrease of Endothelin Receptor Subtype ETB and Release of COX-Derived Products Contribute to Endothelial Dysfunction of Porcine Epicardial Coronary Arteries in Left Ventricular Hypertrophy, Journal of Cardiovascular Pharmacology. 45(6):499-508, June 2005., Department of pharmacology, Montreal, Canada, 2005

Y. Lamarche, MD a , b , O. Malo, MSc a , E. Thorin, PhD b , A. Denault, MD d , M. Carrier, MD, MSc a , b , J. Roy, CPP e , L.P. Perrault, MD, PhD, Inhaled but not intravenous milrinone prevents pulmonary endothelial dysfunction after cardiopulmonary bypass, J Thorac Cardiovasc Surg 2005;130:83-92, Research Center, Montreal Heart Institute, Montreal, Quebec, Canada, 2005

G Rosi, Z Lazi, S Pantovi, M Ros, Phenylethylamine effects on histamine-induced contraction of isolated guinea-pig trachea rings (69.21 Ko), Jugoslov Med Biohem 24: 95–97, 2005, Medical Faculty, University of Kragujevac, Serbia and Montenegro, 2005

Husnia Marrif, Aria Schifman, Zaruhi Stepanyan, Marc-Antoine Gillis, Angelino Calderone, Roy E. Weiss, Jacques Samarut and J. Enrique Silva, Temperature Homeostasis in Transgenic Mice Lacking Thyroid Hormone Receptor-Gene Products, Endocrinology Vol. 146, No. 7 2872-2884, Division of Endocrinology (H.M., A.S., Z.S., J.E.S.), Jewish General Hospital, McGill University, Montréal, Québec, Canada H3T 1E2; Montréal Heart Institute (M.-A.G., A.C.), Montréal, Québec, Canada H1T 1C8; Department of Medicine (R.E.W.), University of Chicago, Chicago, Illinois 60637; and Ecole Normal Superior (J.S.), 69364 Lyon Cadex 07, France, 2005

Remon W. M. van Den Broek, Pankaj Bhalla, Antoinette Maasen Van Den Brink, rené de Vries, hari S. Sharma and Pramod R. Saxena , Characterisation of Sumatriptan-induced contractions in human isolated blood vessels using selective 5-HT1B and 5-HT1D receptor antagonists and in situ hybidisation (436.21 Ko), Cephalalgia , University of Rotterdam, 2004

Julien Hanson1, Stephanie Rolin1, Denis Reynaud, Na Qiao, Leanne P. Kelley, Helen M. Reid, François Valentin, John Tippins, B. Therese Kinsella, Bernard Masereel, Cecil Pace-Asciak, Bernard Pirotte, and Jean-Michel Dogné , In Vitro and in Vivo Pharmacological Characterization of BM-613, Journal of Pharmacology And Experimental Therapeutics
313:293-301, 2005, Natural and Synthetic Drugs Research Centre, Department of Pharmacy, Laboratory of Medicinal Chemistry, University of Liège, Liège, Belgium, 2004

Magnus Bäck; Hong Qiu; Jesper Z. Haeggström; Kiyoto Sakata , Leukotriene B4 is an indirectly acting vasoconstrictor in guinea pig aorta via an inductible type of BLT receptor (23.62 Ko), Am J Physiol Heart Circ Physiol 287: H419-H424, 2004 , Karolinska Institute , 2004

Dinesh Srinivasan1, Leah R Burbach1, Donald V Daniels1, Anthony P D W Ford1 and Anindya Bhattacharya1, Pharmacological characterization of canine bradykinin receptors in prostatic culture and in isolated prostate (244.62 Ko), British Journal of Pharmacology (2004) 142, 297−304, Roche Pharmaceuticals, R2-101, 3431 Hillview Avenue, Palo Alto, CA 94304, U.S.A., 2004

S. Rolin; J.M. Dogne; C. Vastersaegher; J. Hanson; B. Masereel, Pharmacological evaluation of both enantiomers of (R,S)-BM-591 as thromboxane A2 receptor antagonists and thromboxane synthase inhibitors (169.32 Ko), Postaglandins & other Lipid Mediators 74 (2004) 75-86, University of Namur, University of Liège, 2004

Renaud Robert; Vincent Thoreau; Caroline Norez; Anne Cantereau; alain Kitzis; Yvette Mettey; Christian Rogier; Frédéric Becq , Regulation of the Cystic Fibrosis Transmembrane Conductance Regulator Channel by β-adrenergic-agonists and VIP in Rat Smooth Muscle Cells and its role in vasorelaxation. (317.98 Ko), The American Society for Biochemistry and Molecular Biology; March 2004 , Université de Poitiers; CHU de Poitiers; Faculté de Medecine de Poitiers , 2004

Claudine Serradeil-Le Gal; Gerard Valette; Loic Foulon; Guy Germain; Charles Advenier; Emmanuel Naline; Marc Bardou; Jean-Pierre Martinolle; Brigitte Pouzet; Danielle Raufaste; Corinne Garcia; Eleonore Double-Cazanave; Maxime Pauly; Marc Pascal; Alain Barbier; Bernard Scatton; Jean-Pierre Maffrand; Gerard Le Fur, SSR126768A: a new selective and orally-active oxytocin receptor antagonist for the prevention of preterm labor, The Journal of Pharmacology and Experimental Therapeutics Fast Forward, January 13, 2004; 10.1124, Sanofi-Synthelabo Recherche, 2004

Kiyoto Sakata; Magnus Bäck; Sven-Erik Dahlén, The contractile action of leukotriene B4 in the guinea-pig lung involves a vascular component (26.51 Ko), British Journal of Pharmacology 141:449-456, Karolinska Institute, 2004

Arbin, Valerie *; Claperon, Nicole +; Fournie-Zaluski, Marie-Claude +; Roques, Bernard P. +; Peyroux, Jacques *, Effects of Dual Angiotensin-Converting Enzyme and Neutral Endopeptidase 24-11 Chronic Inhibition by Mixanpril on Insulin Sensitivity in Lean and Obese Zucker Rats., Journal of Cardiovascular Pharmacology. 41(2):254-264, February 2003., UNIVERSITE RENE DESCARTES PARIS V - FACULTE DE PHARMACIE, Paris, 2003

Jean-Christophe Schneider; Driss El Kebir; Christiane Chéreau; Sophie Lanone; Xiao-Lin Huang; Anthony S. De Buys Roessingh; Jean-Christophe Mercier; Josette Dall'Ava-Santucci; A. Tuan Dinh-Xuan, Involvement of CA2+/ calmodulin-dependent protein kinase II in endothelial NO production and endothelium-dependent relaxation, Am J Physiol Heart Circ Physiol 284: H2311-H2319, 2003, Université Paris 5 Cochin, Hôpital Robert Debré, 2003

Li Ding-Zhou;Catherine Marchand-Verrecchia; Bruno Palmier; Nicole Croci; Pierre-Etienne Chabrier; Michel Plotkine; Isabelle Margaill, Neuroprotective Effects of (S)-N-[4-[4(3,4-Dihydro-6hydroxy-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl) carbonyl]-1-piperazinyl]phenyl]-2-thiophenecarboximid-amide (BN80933), an Inhibitor of Neuronal Nitric-Oxide Synthase and an Antioxidant, in Model of Transient Focal Cerebral Ischemia in Mice (142.23 Ko), JPET 306:588-594, 2003, Université René Descartes, Paris; Institut Henri Beaufour, Les Ulis, 2003

Nicole Villeneuve; Ana Fortuno; Marie Sauvage; Nancy Fournier; Christine Breugnot; Christine Jacquemin; Christine Petit; Willy Gosgnach; Nathalie Carpentier; Paul Vanhoutte; Jean-Paul Vilaine, Persistence of the Nitric Oxide Pathway in the Aorta of Hypercholesterolemic Apolipoprotein-E-Deficient Mice (224.8 Ko), Journal of Vascular Research 2003;40:87-96, Institut de Recherches Servier Suresnes, 2003

Patrick Berger; François Laurent; Hugues Begueret; Vincent Perot; Rozen Rouiller; Chantal Raherison; Mathieu Molimard; Roger Marthan; J. Manuel Tunon-de-Lara , Structure and Function of Small Airways in Smokers: Relationship between Air Trapping at CT and Airway Inflammation, Radiology 2003; 228: 85-94 , Université de Bordeaux II; CHU de Bordeaux , 2003

Roland G. Demaria; Olivier Malo; Michel Carrier; Louis P. Perrault, The Monoshunt: a new intracoronary shunt design to avoid distal endothelial dysfunction during off-pump coronary artery bypass (OPCAB) (174.15 Ko), Interactive Cardiovascular and Thoracic Surgery 2 (2003) 281-286, Montreal Heart Institute; Arnaud de Villeneuve Teaching Hospital, montpellier; University of Montreal, 2003

Etienne Roux ; Michel duvert ; Roger Marthan , Combined effect of chronic hypoxia and in vitro exposure to gas pollutants on airway reactivity. (125.15 Ko), American Journal Physiol Lung Cell Mol Physiol 283: L628-L635, 2002 , Université de Bordeaux , 2002

Jean-Christophe Schneider; Driss El Kebir; Christiane Chéreau; Jean-Christophe Mercier; Josette Dall'Ava-Santucci; A. Tuan Dinh-Xuan, Involvement of NA+/CA2+ exchanger in endothelial NO production and endothelium-dependent relaxation (344.02 Ko), Am J Physiol Heart Circ Physiol 283: H837-H844, 2002, Université Paris 5 Cochin; Hôpital Robert Debré, 2002

Dragan Pavlovic, Modulation of the Airway Tone by the Epithelium: Effects of Carbicisteine (1.12 Mo), , The Medical Faculty Ernst Moritz Arndt University Greifswald, 2002

Laurence Walch; Xavier Norel; Magnus Bäck; Jean-Pierre Gascard; Sven-Erik Dahlén; Charles Brink, Pharmacological evidence for a novel cysteinyl-leukotriene receptor suntype in human pulmonary artery smooth muscle, British Journal of Pharmacology 137: 1339-1345;(2002) , CNRS FRE 2536, Hôpital Broussais, Paris 14; CNRS ESA 8078, Centre Chirurgical Marie Lannelongue, le Plessis Robinson; Karolinska Insitut of Stockholm, 2002

F.J. Mercier; E. Naline; M. Bardou; O. Georges; A. Denjean; D. Benhamou; C. Advenier, Relaxation of proximal and distal isolated human bronchi by halothane, isoflurane and desflurane (325.1 Ko), Eur Respir J 2002; 20:286-292, Université Paris-Ouest; UFR Biomédicale des St-Pères; Hôpital Béclère; Laboratoire Lab-Guigui et Associés; CHU de Poitiers, 2002

B. Christophe; B. Carlier; P. Chatelain; M. Peck. R. Massingham, β3-adrenoceptors mediate relaxation induced by isoproterenol on the isolated guinea pig gall bladder (403.44 Ko), EPHAR meeting poster, july 6-9 2001, UCB Pharma Braine, 2001

Magnus Bäck; Maria Kumlin; Ian A. Cotgreave; Sven-Erik Dahlén, An alternative pathway for metabolism of leukotriene D4: effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea, Br. J; Pharmacol.(2001), 133: 1134-1144, Karolinska Institute, 2001

Sébastien Bonnet; jean-Marc Hyvelin; Pierre Bonnet; Roger Marthan; Jean-Pierre Savineau, Chronic hypoxia-induced spontaneous and rhythmic contractions in the rat main pulmonary artery (205.75 Ko), The American Physiological Society 2001, 1040-0605, Université de Bordeaux II, 2001

Sébastien Bonnet;Alexandra Belus; jean-Marc Hyvelin; Etienne Roux; Roger Marthan; Jean-Pierre Savineau, Effect of chronic hypoxia on agonist-induced tone and calcium signaling in rat pulmonary artery (197.52 Ko), American Journal Physiol Lung Cell Mol Physiol 281: L193-L201, 2001, Université de Bordeaux II, 2001

Richard H.J. Bruijns; Hidde Bult, Effect of local cytochalasin D delivery on smooth muscle cell migration and on collar-induced intimal hyperplasia in the rabbit carotid artery, British Journal of Pharmacology 134: 473-483 (2001), University of Antwerp, 2001

Marc W. Merx; Ulrich Flögel; Thomas Stumpe; Axel Gôdecke; Ulrich K. M. Decking; Jürgen Schrader, Myoglobin facilitates oxygen diffusion (640.11 Ko), The FASEB Journal express article 10.1096/fj.00-0497fje, 5 février 2001, Heinrich-Heine-Universität of Düsseldorf, 2001

Ulrich Flögel; Marc W. Merx; Axel Gödecke; Ulrich K. M. Decking; Jürgen Schrader, Myoglobin: A scavenger of bioactive NO (209.66 Ko), PNAS-January 16, 2001; vol 98, n°2, 735-740, Heinrich-Heine-Universität of Düsseldorf, 2001

Namni Aiyar; Robert A. Daines; Jyoti Disa; Pamela A. Chambers; Charles F. Sauermelch; Marie-J. Quiniou; Nassirah Khandoudi; bernard Gout; Stephen A. Douglas; Robert N. Willette, Pharmacology of SB-273779, a Nonpeptide Calcitonin Gene-Related Peptide 1 Receptor Antagonist (175.51 Ko), The Journal of Pharmacology and experimental therapeutics JPET 296: 768-775, 2001, SmithKline Beecham Pharmaceuticals of Pennsylvania; SmithKline Beecham Pharmaceuticals of Saint-Grégoire, 2001

Magnus Bäck, Studies of Receptors and Modulatory Mechanisms in Functional Responses to Cysteinyl-leukotrienes in Smooth Muscle, , Karolinska Institute, 2001

B. Becker; M.-H. Antoine; Q.-A. Nguyen; B. Rigo; K.E. Cosgrove; P.D. Barnes; M.J. Dunne; B. Pirotte; P. Lebrun, Synthesis and characterization of a quinolinic compound activating ATP-sensitive K+ channels in endocrine and smooth muscle tissues, British Journal of Pharmacology 134:375-385 (2001), Université libre de Bruxelles; Ecole des Hautes Etudes Industrielles de Lille; University of Sheffield; Université de Liège, 2001

Inge S. Geerts; Guido R.Y. De Meyer; Hidde Bult , Collar-induced elevation of mRNA and functional activity of 5-HT1B receptor in the rabbit carotid artery, British Journal of Pharmacology 131: 1723-1731 (2000), University of Antwerp, 2000

A. Maassen VanDenBrink; R.W.M. van den Broek; R. de Vries; A.J.J.C. Bogers; C.J.J. Avezaat; P.R. Saxena, Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels , Neurology 2000; 55: 1524-1530, Erasmus University Medical Center Rotterdam, 2000

M. Bardou; C. Loustalot; J. Cortijo; B. Simon; E. Naline; M. Dumas; S. Esteve; T. Croci; P. Chalon; R. Frydman; P. Sagot; L. Manara; E.J. Morcillo; C. Advenier, Functional, biochemical and molecular biological evidence for a possible β3-adrenoceptor in human near-term myometrium, British Journal of Pharmacology 130: 1960-1966 (2000), Faculté de Médecinde Paris-Ouest (6ème); CHU du Bocage de Dijon; CHU Antoine Béclère de Clamart; University of Valencia; Faculté de Médecine de Dijon; Research Center Sanofi Midy of Milan; Sanofi Recherche de Labège, 2000

Louis P. Perrault; Florence Mahlberg; Christine Breugnot; Jean-Pierre Bidouard; Nicole Villemeuve; Jean-Paul Vilaine; Paul M. Vanhoutte, Hypercholesterolemia Increases Coronary Endothelial Dysfunction, Lipid Content, and Accelerated Atherosclerosis After Heart Transplantation (198.3 Ko), Arterioscler Thromb Vasc Biol. 2000; 20: 728-736, Montreal Heart Institute; Institut de Recherches Servier Suresnes, 2000

Rémon W.M. van den Broek; antoinette Maassen VanDenBrink; René de Vries; Ad J.J.C. Bogers; Alexander P.A. Stegmann; Cees J. Avezaat; Pramod R. Saxena, Pharmacological analysis of contractile effects of eletripan and sumatriptan on human isolated blood vessels (4.1 Mo), European Journal of Pharmacology 407 (2000) 165-173, Erasmus University Medical Center Rotterdam , 2000

Catherine I. Chardigny; Kristien Van der Perre; Serge Simonet; Jean-Jacques Descombes; Jean-Noël Fabiani; Tony J. Verbeuren, Platelets and prostacyclin in arterial bypasses: implications for coronary artery surgery, Ann Thorac Surg 2000; 69: 513-519, Institut de Recherches Servier Suresnes, 2000

Jin Bo Su; Rémi Hoüel; François Héloire; Fabrice Barbe; Fabrizio Beverelli; Lucien Sambin; Alain Castaigne; Alain Berdeaux; Bertrand Crozatier; Luc Hittinger, Stimulation of Bradykinin B1 Receptors Induces Vasodilation in Conductance and Resistance Coronary Vessels in Conscious Dogs Comparison with B2 Receptor Stimulation (147.74 Ko), Circulation 2000; 101: 1848-1853, INSERM U400 Créteil; Hôpital Kremlin-Bicêtre, 2000

Etienne Roux; Jean-Marc Hyvelin; Jean-Pierre Savineau; Roger Marthan, Human Isolated Airway Contraction Interaction between Air Pollutants and Passive Sensitization (87.86 Ko), Am J Respir. Crit Care Med. Vol 160, 1999, 439-445, Université de Bordeaux II, 1999

Sophie Parmentier; Georg Andrees Bôhme; Dominique Lerouet; Dominique Damour; Jean-Marie Stutzmann; Isabelle Margaill; Michel Plotkine, Selective inhibition of inducible nitric oxide synthase prevents ischaemic brain injury , British Journal of Pharmacology 127: 546-552 (1999), Université René Descartes, Paris; Rhône-Poulenc Rorer S.A. de Vitry-Alfortville, 1999

Céline Rouaud; Marcel Delaforge; Marielle Anger-Leroy; Gaël Le Filliatre; Michel Finet; Rémy Hanf, The cyclo-oxygenase-dependent regulation of rabbit vein contraction: evidence for a prostaglandin E2-mediated relaxation, British Journal of Pharmacology 126: 35-44, Laboratoire INNOTHERA d'Arcueil; CNRS URA 400 de Paris 6, 1999

Jean-Marc Hyvelin; Christelle Guibert; Roger Mathan; Jean-Pierre Savineau, Cellular mechanisms and role of endothelin-1-induced calcium oscillations in pulmonary arterial myocytes (233.35 Ko), The American Physiological Society 1998, 1040-0605, Université de Bordeaux II, 1998

D. Pavlovic; N. Viires; C. Zedda; M. Fournier; M. Aubier , Effects of corticosteroids on epithelial structure and smooth muscle function of rat trachea (4.12 Mo), European Respiratory Journal 1998: 11: 575-582 , INSERM 408 Xavier Bichat , 1998

Etienne Roux; Jean-Marc Hyvelin; Jean-Pierre Savineau; Roger Marthan, Calcium Signaling in Airway Smooth Muscle Cells Is Altered by In Vitro Exposure to the Alhehyde Acrolein (127.37 Ko), Am J Respir. Cell Mol. Biol. Vol 19, 1998, 437-444, INSERM C.R.I.9806; Université Bordeaux II, 1997

Paul Schaeffer; anne-Marie Mares; Frédérique Dol; Françoise Bono; Jean-Marc Herbert, Coagulation Factor Xa Induces Endothelium-Dependent Relaxations in Rat Aorta, Circulation Research 1997; 81: 824-828, Sanofi Recherche Toulouse, 1997

Michael Fayon; Abdellaziz Ben-Jebria; Christophe Elleau; Dominique Carles; Jean-Louis Demarquez; Jean-Pierre Savineau; Roger Mathan , Human airway smooth muscle responsiveness in neonatal lung specimens (11.32 Mo), The American Physiological Society 1994, 1040-0605 , Université de Bordeaux II; Hôpital Pellegrin de Bordeaux , 1994

Abdellaziz Ben-Jebria; Roger Marthan; Max Rossetti; Jean-Pierre Savineau; James S. Ultman, Human Bronchial Smooth Muscle Responsiveness after In Vitro Exposure to Acrolein (2.56 Mo), Am J Respir. Crit Care Med. Vol 149, 1994, 382-386, Université de Bordeaux II, 1994

Vincent Richard; Jean-Paul Henry; Christian Thuillez , Is Guanidino Succinate a Precursor for Nitric Oxide Synthesis in Rat Vascular Tissue? (2.45 Mo), Journal of Cardiovascular Pharmacology 24:50-54 1994 , VACOMED Rouen , 1994

Abdellaziz Ben-Jebria; Roger Marthan; Max Rossetti; Jean-Pierre Savineau; James S. Ultman, Effect of in vitro exposure to acrolein on carbachol responses in rat trachealis muscle (4.26 Mo), Respiration Physiology, 93 (1993) 111-123, Université de Bordeaux II, 1993

Abdellaziz Ben-Jebria; Roger Marthan; Max Rossetti; Jean-Pierre Savineau, Effect of passive sensitization on the mechanical activity of human isolated bronchial smooth muscle induced by substance P, neurokinin A and VIP (3.1 Mo), Br. J; Pharmacol.(1993), 109, 131-136, Université de Bordeaux II, 1993

René Robert; Béatrice Chapelain; Thierry Jena; Gervais Néliat, Interleukin-1 impairs both Vascular contraction and Relaxation in Rabbit isolated Aorta (7.77 Mo), Biochemical and Biophysical Research Communications, vol 182, n°2, 1992, 733-739, CEREP Celle l'Evescault, 1992

Jean-Vivien Mombouli; Stephane Illiano; Tetsuhiko Nagao; Timothy Scott-Burden; Paul M. Vanhoutte, Potentiation of Endothelium-Dependent Relaxations to Bradykinin by Angiotensin I Converting Enzyme Inhibitors in Canine Coronary Atery Involves Both Endothelium-Derived Relaxing and Hyperpolarizing Factors (4.17 Mo), Circulation Research vol 71, n°1, July 192, Baylor College of Medecine from Houston, 1992

Laurent Mahe; Beatrice Chapelain; Gervais Neliat; Yves-Michel Gargouil, The role of α- and β-adrenoceptors in the response to noradrenaline of lymphatic vessels isolated from the bovine mesentery (2.93 Mo), European Journal of Pharmacology 167 (1989) 31-39, Laboratoire Celaster de Lusignan, 1989

application : myograph

top of page

Emile Andriambeloson; Catherine Cannet; Charles Pally; Bernd Klanke; Christian Bruns; Hans-Gunter Zerwes; Marc Bigaud, Transplantation-Induced Functional/Morphological Changes in Rat Aorta Allografts Differ from Those in Arteries of Rat Kidney Allografts, American Journal of Transplantation Volume 4 Issue 2 Page 188 - February 2004, , 2004

application : physiology

top of page

Jie Liu; Sandor Batkai; Pal Pacher; Judith Harvey-White; Jens A. Wagner; Benjamin F. Cravatt; Bin Gao; George Kunos, Lipopolysaccharide Induces Anandamide Synthesis in Macrophages via CD14/MAPK/Phosphoinositide 3-Kinase/NF-kB Independently of Platelet-activating Factor (223.97 Ko), The Journal of Biological Chemistry vol 278, no45, november 7, 2003, 45034-45039, National Inst. On Alcohol abuse and Alcoholism of Bethesda; University of Wuerzburg; Scipps Institute of LaJolla, 2003

application : pulmonary

top of page

Karim H Shalaby1, Leslie G Gold2, Thomas F Schuessler2, James G Martin1 and Annette Robichaud2, Combined forced oscillation and forced expiration measurements in mice for the assessment of airway hyperresponsiveness (781.54 Ko), Respiratory Research 2010, 11:82, ¹Meakins Christie Laboratories, McGill University, Montreal, Québec, Canada and ²SCIREQ Scientific Respiratory Equipment Inc., Montreal, Québec, Canada, 2010

Baher Fahmy a,1, Liren Ding a,2, Dahui You a, Slawo Lomnicki b, Barry Dellinger b, Stephania A. Cormier a,*, in vitro and in vivo assessment of pulmonary risk associated with exposure to combustion generated fine particles (565.24 Ko), Environmental Toxicology and Pharmacology 29 (2010) 173-182, ^a Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, LA, USA, ^b Department of Chemistry, Louisiana State University, Baton Rouge, LA, USA, 2010

Alexandre C Motta † 1, Joost LM Vissers † 2, Renee Gras1, Betty CAM Van Esch2, Antoon JM Van Oosterhout * 1 and Martijn C Nawijn1, GITR signaling potentiates airway hyperresponsiveness by enhancing Th2 cell activity in a mouse model of asthma (261.41 Ko), Respiratory Research 2009, 10:93 doi:10.1186/1465-9921-10-93, 1Laboratory of Allergology and Pulmonary diseases, Department of Pathology and Medical Biology, University Medical Centre Groningen (UMCG), Groningen University, Groningen, The Netherlands and 2Pharmacology and Pathophysiology, UIPS, Faculty of Sciences, Utrecht University, Utrecht, The Netherlands, 2009

P.J.M. Janssen, M. Peschar, M.S. Teunissen, H.H. Emmen and W.J.A.M. Frieling, A head-out plethysmography set–up for respiratory safety assessment after oral or intravenous and during inhalatory administration of a drug or chemical. (2.19 Mo), AIT 2008 Scientific Poster Presentation, Notox, 2008

Emilie Doz2,*, Nicolas Noulin2,*,**, Elisabeth Boichot***, Isabelle Guénon***, Lizette Fick****, Marc Le Bert*, Vincent Lagente***, Bernhard Ryffel3,*, Bruno Schnyder*, Valérie F. J. Quesniaux* and Isabelle Couillin3,*, Cigarette smoke-induced pulmonary inflammation is TLR4/MyD88 and IL-1R1/MyD88 signaling dependent (594.41 Ko), The Journal of Immunology, 2008, 180, 1169-1178, * University of Orleans and Centre National de la Recherche Scientifique UMR6218, Molecular Immunology and Embryology, **Key-Obs S. A., Orleans, France; ***Institut National de la Santé et de la Recherche Médicale U620, University of Rennes, Rennes, France; and ****Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Cape Town, Republic of South Africa, 2008

Aidan K. Curran 1, Josh Burton 2, Susan Skeans1, Devon Landers 1, Shannon OBrien 2 and Richard W. Chapman 1., Continuous measures of breathing and phase angle in conscious cynomolgus monkeys. (352.38 Ko), Schering-Plough Research Institute - Poster presentation at Experimental Biology 2008, 1Pulmonary and Peripheral Neurobiology, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA and 2emka TECHNOLOGIES Inc., Falls Church VA 22046, USA, 2008

Sofia Jonasson,1 Linda Swedin,2 Maria Lundqvist,1 Göran Hedenstierna,1 Sven-Erik Dahlén,2 and Josephine Hjoberg,1, Different effects of deep inspirations on central and peripheral airways in healthy and allergen-challenged mice, Respir Res. 2008; 9(1): 23., 1 Department of Medical Sciences, Clinical Physiology, Uppsala University, Uppsala, Sweden - 2 The National Institute of Environmental Medicine, Division of Physiology, Karolinska Institutet, Stockholm, Sweden, 2008

Sandra Picard, Sonia Rompion, Sonia Goineau, Philippe Guillaume, Mouse - More Sensitive Than Rat or Guinea Pig for Assessing Respiratory Depressant Potential of Drugs (394.13 Ko), SPS Scientific Poster Presentation, Porsolt & Partners Pharmacology, 2008

Minjie Feng1, Steven Whitesall2, Yunyu Zhang3, Martin Beibel4, Louis D’Alecy2, and Keith DiPetrillo1, Validation of Volume-Pressure Recording Tail Cuff Blood Pressure Measurements (178.73 Ko), American Journal of Hypertension., 1 Novartis Institutes for BioMedical Research & Novartis Pharmaceutical Company, East Hanover, NJ 07936 - 2 Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109 - 3 Novartis Institutes for BioMedical Research, Cambridge, MA 02139 - 4 Novartis Pharma AG, Basel, Switzerland, 2008

Annette Roblchaud, PhD, The value of sophisticated measurements of airway hyperresponsiveness in pre-clinical research (1.23 Mo), Medical Science Digest Vol 33(7), 2007, The article was written on behalf of SCIREQ Scientific Respiratory Equipment Inc . - manufacturer of flexiVent., 2007

Roux J.C., Dura E., Moncla A., Mancini J., Villard L., Treatment with desipramine improves breathing and survival in a mouse model for Rett syndrome. (687.13 Ko), The European journal of neuroscience 2007;25(7):1915-22., INSERM, U491, Faculté de Médecine de La Timone, Marseille, F-13385, France, 2007

Dieudonnée Togbe *, Silvia Schnyder-Candrian *, Bruno Schnyder *, Isabelle Couillin *, Isabelle Maillet *, Franck Bihl , Danielle Malo **, Bernhard Ryffel *, and Valerie F. J. Quesniaux*, TLR4 gene dosage contributes to endotoxin-induced acute respiratory inflammation. (235.51 Ko), Journal of Leukocyte Biology doi:10.1189/jlb.0206099 , *UMR, CNRS (Centre National de la Recherche Scientifique), Molecular Immunology and Embryology (IEM), Orléans, France; and **Biomedical Research Foundation, SBF, Matzingen, and Department of Medicine and Human Genetics, McGill University, Montréal, Quebec, Canada, 2006

X. Havaux*, A. Zeine, A. Dits and O. Denis, A new mouse model of lung allergy induced by the spores of Alternaria alternata and Cladosporium herbarum molds (720.98 Ko), Clinical & Experimental Immunology, Cardiology Unit, Université Catholique de Louvain and Allergology Unit, Pasteur Institute of Brussels, Brussels. Belgium., 2005

Isabelle Spik, Céline Brénuchon, Véronique Angéli, Delphine Staumont, Sébastien Fleury, Monique Capron, François Trottein and David Dombrowicz, Activation of the Prostaglandin D2 Receptor DP2/CRTH2 Increases Allergic Inflammation in Mouse (302.63 Ko), The Journal of Immunology, 2005, 174: 3703-3708., Unité 547, Institut National de la Santé et de la Recherche Médicale, Institut Fédératif de Recherche 17, Institut Pasteur de Lille, Lille, France, 2005

Mohamed S. Arredouani1, Ahmad Kasran1, Jeroen A. Vanoirbeek2, Frank G. Berger3, Heinz Baumann4 and Jan L. Ceuppens1, Haptoglobin dampens endotoxin-induced inflammatory effects both in vitro and in vivo (270.64 Ko), Immunology 114, 263-271, Laboratory for Experimental Immunology and 2Laboratory for Lung Toxicology, Gasthuisberg University Hospital, Catholic University of Leuven, Leuven, Belgium, 2005

Leonie S. van Rijt1, Steffen Jung2, Alex KleinJan1, Nanda Vos1, Monique Willart1, Catherine Duez3, Henk C. Hoogsteden1, and Bart N. Lambrecht, In vivo depletion of lung CD11c+ dendritic cells during allergen challenge abrogates the characteristic features of asthma (2.52 Mo), JEM, Volume 201, Number 6, 981-991, Department of Pulmonary Medicine, Erasmus MC, 3015 GE Rotterdam, Netherlands Institut National de la Santé et de la Recherche Médicale U416, Institut Pasteur de Lille, 59019 Lille, France, 2005

Ehud Keinan,a,*, Aaron Alt,a Gail Amir,b Lea Bentur,c Haim Bibid and David Shoseyo, Natural ozone scavenger prevents asthma in sensitized rats (456.04 Ko), Bioorganic & Medicinal Chemistry 13 (2005) 557–562, Department of Chemistry and Institute of Catalysis Science and Technology, Technion –Israel Institute of Technology, 2005

Sarit Offer,1 Saul Yedgar,2 Ouri Schwob,2 Miron Krimsky,2 Haim Bibi,3 Abraham Eliraz,4 Zecharia Madar,1 and David Shoseyov, Negative feedback between secretory and cytosolic phospholipase A2 and their opposing roles in ovalbumin-induced bronchoconstriction in rats, Am J Physiol Lung Cell Mol Physiol 288: L523-L529, 2005, Department of Pediatrics, Barzilai Medical Center, Ashkelon, Israel, 2005

E. Pinelli*, C. Withagen†, M. Fonville‡, A. Verlaan†, J. Dormans†, H. van Loveren†, G. Nicoll‡, R. M. Maizels‡ and J. van der Giessen, Persistent airway hyper-responsiveness and inflammation in Toxocara canis-infected BALB/c mice, Clinical & Experimental Allergy, Diagnostic Laboratory for Infectious Diseases and Perinatal Screening, Department of Parasitology and Mycology, National Institute for Public Health and the Environment (RIVM), PO Box 1, 3720 BA Bilthoven, The Netherlands., 2005

Wiebke Scherf 1, Stefan Burdach 2, Gesine Hansen, Reduced expression of transforming growth factor 1 exacerbates pathology in an experimental asthma model, Department of Pediatrics, Division of Allergy and Pulmonology, Martin-Luther-University Halle-Wittenberg, Halle, Germany, Department of Pediatrics, Division of Allergy and Pulmonology, Martin-Luther-University Halle-Wittenberg, D-06120 Halle, Germany, 2005

Christian Frei1,2,+, Mireille Galloni3, Ernst Hafen2 and Bruce A Edgar1, The Drosophila mitochondrial ribosomal protein mRpL12 is required for Cyclin D/Cdk4-driven growth, The EMBO Journal, Vol. 24, No. 3 pp. 623-634, 2005, INSERM-UM2 E343, Université de Montpellier 2, Montpellier, France, 2005

Per Gerde A1, Pär Ewing A1, Lena Låstbom A1, Åke Ryrfeldt A1, Juri Waher A2, Göran Lidén A, A Novel Method to Aerosolize Powder for Short Inhalation Exposures at High Concentrations: Isolated Rat Lungs Exposed to Respirable Diesel Soot, Inhalation Toxicology Volume 16, Number 1 / January 2004, National Institute of Environmental Medicine, Division of Lung Physiology, Karolinska Institutet, Stockholm, Sweden, 2004

S. Fortier; R. G. DeMaria; Y. Lamarche; O. Malo; A. Denault; F. Desjardins; M. Carrier; L. P. Perrault, Inhaled prostacyclin reduces cardiopulmonary bypass-induced pulmonary endothelial dysfunction via increased cyclic adenosine monophosphate levels (168.97 Ko), J Thorac Cardiovasc Surg 2004; 128:109-116, Montreal Heart Institute; CHU Arnaud de Villeneuve, Montpellier, 2004

Kloek, I. Van Ark, g. Folkerts, f. De Clerck, N. Bloksma, F.P. Nijkamp, Modulation of hyperresponsiveness by glutathione in a murine in vivo model of allergic asthma (164.21 Ko), , University of Utrecht, 2004

P. W. Hellings 1, 2, J. L. Ceuppens 3, Mouse models of global airway allergy: what have we learned and what should we do next?, AllergyVolume 59 Page 914 - September 2004, Laboratory of Experimental Immunology University Hospitals Leuven, Belgium, 2004

K. Blümchen, K. Gerhold, I. Thorade, C. Seib, U. Wahn and E. Hamelmann, Oral administration of desloratadine prior to sensitization prevents allergen-induced airway inflammation and hyper-reactivity in mice, Clinical & Experimental Allergy Volume 34 Page 1124 - July 2004, Department of Pediatric Pneumology and Immunology, University Hospital Charite, Berlin, Germany, 2004

David J. Halloya, Sandrine Bouhetb, Isabelle P. Oswaldb, Michèle Goret-Nicaisec, Marylène Kobischd, Jacques Mainile and Pascal G. Gustina , Pathophysiological changes occurring during Escherichia coli endotoxin and Pasteurella multocida challenge in piglets: relationship with cough and temperature and predicitive value for intensity of lesions (569.28 Ko), Vet. Res. 35 (2004) 309-324, Faculty of Veterinary Medicine, University of Liège, 2004

Willem Bergers A1, Dory Horst A1, Marloes Joosen, Respiration-Based Measurement of Lung Deposition of a Fluorescent Dextrane Aerosol in a Marmoset Monkey, Inhalation Toxicology, TNO Prins Maurits Laboratory, Division Chemical and Biological Protection, Rijswijk, The Netherlands, 2004

Jeroen A.J. Vanoirbeek; Maciej Tarkowski; Jan L. Ceuppens; Erik K. Verbeken; Benoit Nemery; Peter H. M. Hoet, Respiratory response to toluene diisocyanate depends on prior frequency and concentration of dermal sensitization in mice (321.59 Ko), TOXSCI-04-0031, May 5 2004, University of Leuven, 2004

Jan H. Reiling and Ernst Hafen, The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila (477.54 Ko), GENES & DEVELOPMENT 18:2879-2892, 2004 , Zoologisches Institut, Universität Zürich, CH-8057 Zürich, Switzerland, 2004

Claire Brown; Malika Fezoui; William M Selig; Carl E Schwartz; James Ellis, Antitussive activity of sigma-1 receptor agonists in guinea-pig,
Br J Pharmacol, December 22, 2003; doi:10.1038, UCB Pharma Cambridge, 2003

D. T. Deurloo*, M. A. T. van Berkel†, B. C. A. M. van Esch*, F. Hofhuis†, F. P. Nijkamp*, M. A. Oosterwegel† and A. J. M. van Oosterhout*, CD28/CTLA4 double deficient mice demonstrate crucial role for B7 co-stimulation in the induction of allergic lower airways disease, Clinical & Experimental Allergy Volume 33 Page 1297 - September 2003, Department of Pharmacology and Pathophysiology, Faculty of Pharmaceutical Sciences, Utrecht University, Utrecht, the Netherlands and †Department of Immunology, University Medical Center, Utrecht, the Netherlands, 2003

Thierry D. Flandre; Pascal L. Leroy; Daniel J.-M. Desmecht , Effect of somatic growth, strain, and sex on double-chamber plethysmographis respiratory function values in healthy mice (9.16 Mo), J Appl Physiol 94: 1129-1136, 2003 , University of Liège , 2003

Yolande Chvatchko; Amanda E.I. Proudfoot; Raphaële Buser; Pierre Juillard; Sami Alouani; Marie Kosco-Vilbois; Anthony J. Coyle; Robert J. Nibbs; Gerry Graham; Robin E. Offord; Timothy N.C. Wells, Inhibition of Airway Inflammation by Amino-Terminally Modified RANTES/CC Chemokine Ligand 5 Analogues Is Not Mediated through CCR3, The Journal of Immunology, 2003, 171: 5498-5506, Serono Pharmaceutical Research Institute; Beatson Institute for Cancer Research of Glasgow; Centre Medical Universitaire de Geneve, 2003

Peter W. Hellings; Ahmad Kasran; Zhanju Liu; Philippe Vandekerhove; Anja Wuyts; Lutgart Overbergh; Chantal Mathieu; Jan L. Ceuppens , Interleukin-17 Orchestrates the Granulocyte Influx into Airways after Allergen Inhalation in a Mouse Model of Allergic Asthma (300.3 Ko), American Journal of Respiratory Cell and Molecular Biology vol 28, 2003 , University of Leuven , 2003

Jason H.T Bates and Charlkes G. Irvin, Measuring lung function in mice: the phenotyping uncertainty principle, Journal of Applied Physiology, The American Physiological Society, University of Vermont, Burlington, Vermont, 2003

Gaetane Woerly; Kohei Honda; Marc Loyens; Jean-Paul Papin; Johan Auwerx; Bart Staels; Monique Capron; David Dombrowicz, Peroxisome Proliferator-activated Receptors á and ã Down-regulate Allergic Inflammation and Eosinophil Activation, The Journal of Experimental Medicine, Volume 198, n°3, 411-421, Intitut Pasteur de Lille; Université de Lille II; Université Louis Pasteur de Illkirch, 2003

Jeroen A.J. Vanoirbeek; Cindy Mandervelt; Albert R. Cunningham; Peter H.M. Hoet; Haiyan Xu; Hadewijch M. Vanhooren; Benoit Nemery, Validity of Methods to Predict the Respiratory Sensitizing Potential of Chemicals: A Study with a Piperidinyl Chlorotriazine Derivative That Caused an Outbreak of Occupational Asthma (268.25 Ko), Toxicological Sciences 76, 338-346 (2003), Katholieke U of Leuven; Louisiana University, 2003

Leenart K. A. Lundblad, Charles G. Irvin, Andy Adler and Jason H.T Bates, A reevaluation of the validity of unrestrained plethysmography in mice, Journal of Applied Physiology, The American Physiological Society, University of Vermont, Burlington, Lund University, Sweden, AIT Corporation, Ottawa, Ontario, Canada, 2002

Thomas Glaab, Heinz G. Hoymann, Jens M. Hohlfeld, Regina, Korolewitz, Matthias Hecht, Yves Alarie, Thomas Tschernig, Armin Braun, Norbert Krug, and Helmut Fabel, Non Invasive Measurement of Midexpiratory flow indicates bronchoconstriction in allergic rats, Journal of Applied Physiology 93: 1208-1214, 2002. First published May 10, 2002, The American Physiological Society-University of Pittsburgh, Pennsylvania, 2002

Henri Burnet; Michelle Bévengut; Fouad Chakri; Céline Bou-Flores; Patrice Coulon; Susana Gaytàn;Rosario Pàsaro; Gérard Hilaire, Altered Respiratory Activity and Respiratory Regulations in Adult Monoamine Oxidase A-Deficient Mice (521.76 Ko), The Journal of Neuroscience, july 15, 2001, 21(14):5212-5221, Ctre Nat° RS&D et Path du Mouv, Bio des Ryth&D, Neuro Cyber cell Marseille; Faculté de biologie de Seville, 2001

Daphne T. Deurloo; Betty C.A.M. van Esch; Claudia L. Hofstra; Frans P. Nijkamp; Antoon J.M. van Oosterhout, CTLA4-IgG Reverses Asthma Manifestations in a Mild but Not in a More "Severe" Ongoing Murine Model (141.26 Ko), American Journal of Respiratory Cell and Molecular Biology vol 25, 2001, Utrecht University, 2001

Anuja Mathew; James A. MacLean Elliot DeHaan; Andrew M. Tager Francis H.Y. Green; Andrew D. Luster, Signal Transducer and Activator of Transcription 6 Controls Chemokine Production and T Helper Cell Type 2 Cell Trafficking in Allergic Pulmonary Inflammation (397.17 Ko), J.Exp.Med Vol 193, n°9, may 7, 2001 1087-1096, Harvard Medical School boston; University of Calgary, 2001

Yolande Chvatchko; Arlene J. Hoogewerf; Alexendra Meyer; Sami Alouani; Pierre Juillard; Raphaele Buser; Francois Conquet; Amanda E.I. Proudfoot; Timothy N.C.Wells; Christine A. Power, A Key Role for CC Chemokine Receptor 4 in Lipopolysaccharide-induced Endotoxic Shock (162.08 Ko), J.Exp.Med Vol 191, n°10, may 15, 2000 1755-1763, Serono Pharmaceutical Research Institute, 2000

Clare M. Lloyd; Tracy Delaney Trang Nguyen; Jane Tian Carlos Martinez-A; Anthony J. Coyle Jose-Carlos Gutierrez-Ramos, CC Chemokine Receptor (CCR)3/ Eotaxin Is Followed by CCR4/ Monocyte-derived Chemokine in Mediating Pulmonary T Helper Lymphocyte Type 2 Recruitment after Serial Antigen Challenge In Vivo, J.Exp.Med Vol 191, n°2, january 17, 2000 265-273, Millenium Pharmaceuticals Inc Cambridge; Université autonome de Madrid, 2000

Laurent L. Couëtil; Frank S. Rosenthal; Chris M. Simpson, Forced expiration: a test for airflow obstruction in horses (228.37 Ko), J Appl Physiol 88: 1870-1879, 2000, Prudue University, Indiana, 2000

Anthony J. Coyle; Clare Lloyd Jane Tian, Trang Nguyen Christina Erikkson; Lin Wang Par Ottoson; Per Persson Tracy Delaney; Sophie Lehar Steve Lin; Louis Poisson Christian Meisel; Thomas Kamradt Torbjorn Bjerke; Douglas Levinson Jose Carlos Gutierrez-Ramos, Crucial Role of the Interleukin 1 Receptor Family Member T1/ST2 in T Helper Cell Type 2-mediated Lung Mucosal Immunne Responses (342.6 Ko), J.Exp.Med Vol 190, n°7, october 4, 1999 895-902, Millenium Pharmaceuticals Inc Cambridge;Astra Draco Lund; Deutsches Rheumaforschung Zemtrum Berlin; Universitatsklinikum Charite Berlin, 1999

Antoon J.M. Van Oosterhout; Betty Van Esch; Gerard Hofman; Claudia L. Hofstra; Ingrid Van Ark Frans P. Nijkamp; Martien L. Kapsenberg Huub F.J. Savelkoul; Frank R. Weller, Allergen Immunotherapy Inhibits Airway Eosinophilia and Hyperresponsiveness Associated with Decreased IL-4 Production by Lymphicytes in a Murine Model of allergic Asthma (89.73 Ko), American Journal of respiratory cell and molecular biology vol.19, pp.622-628, 1998, Utrecht University Erasmus University of Rotterdam Academic Medical Center of Amsterdam, 1998

Shogo Tsuyuki; Junko Tsuyuki Karin Einsle; Manfred Kopf Anthony J. Coyle, Costimulation through B7-2 (CD86) Is Required for the Induction of a Lung Mucosal T Helper Cell 2 (TH2) Immune Response and Altered Airway Responsiveness (174.26 Ko), J.Exp.Med Vol 185, n°9, may 5, 1997 1671-1679, Ciba-Geigy Ltd Basel; R&D dept. Kissei Pharmaceutical Co Ltd Matsumoto; Basel Institute for Immunology, 1997

E. Hamelmann, J. Schwarze, K. Takeda, A. Oshiba, G.L Larsen, C.G. Irvin, and E. W. Gelfand, Non Invasive Measurement of Airway Responsiveness in Allergic Mice Using Barometric Plethysmography, Journal of Applied Physiology, National Jewish Medical and Research Center, Denver, Colorado, 1997

Yolande Chvatchko; Marie H. Kosco-Vilbois; Suzanne Herren; Jean Lefort; Jean-Yves Bonnefoy, Germinal Center Formation and Local Immunoglobulin E (IgE) Production in the Lung after an Airway Antigenic Challenge (775.24 Ko), J.Exp.Med Vol 184, december 1996, 2353-2360, Geneva Biomedical Research Institute; Institut Pasteur Paris, 1996

application : pv loops

top of page

Nicolas Borenstein, DVM, MSca,*, Zhou Jian, MD, MScb, Gaelle Fromont, MD, MScc, Patrick Bruneval, MDe, Mehrak Hekmati, PhDa, Luc Behr, DVM, MSca, François Laborde, MDa, Didier Montarras, PhDf, Emmanuel Le Bret, MD, PhD, Dose-dependent effects of endotoxins on allergen sensitization and challenge in the mouse, J Thorac Cardiovasc Surg 2005;129:1119-1127, IMM Recherche, Centre d’Expérimentation et de Recherche Appliquée, Paris, 2005

Marc W. Merx; Elisa A. Liehn; Uwe Janssens; Rudolf Lütticken; Jürgen Shrader; Peter Hanrath; Christian Weber, HMG-CoA Reductase Inhibitor Simvastatin Profoundly Improves Survival in a Murine model of Sepsis (41.72 Ko), Circulation. 2004; 109:2560-2565, Heinrich-Heine-Universität of Düsseldorf; RWTH Aachen, 2004

Ulrich Warskulat; Ulrich Flögel; Christoph Jacoby; Hans-Georg Hartwig; Michael Thewissen; Marc W. Merx; andrej Molojavyi; Birgit Heller-Stilb; Jürgen Schrader; Dieter Häussinger, Taurine transporter knockout depletes muscle taurine levels and results in severe skeletal muscle impairment but leaves cardiac function uncompromised (185.31 Ko), The FASEB Journal express article 10.1096/fj.03-0496fje, January 20, 2004, Düsseldorf University, 2004

Carsten Wunderlich; Ulrich Flögel; Axel Gödecke; Jacqueline Heger; Jürgen Schrader, Acute Inhibition of Myoglobin Impairs Contractility and Ebergy State of iNOS-Overexpressing Hearts, Circulation Research. 2003; 92:1352, Heinrich-Heine-Universität of Düsseldorf, 2003

Shintaro Nemoto; Gilberto Defreitas; Blase A. Carabello , Cardiac Catheterization Technique in a Closed-Chest Murine Model (136.25 Ko), The American Association for Laboratory Animal Science Volume 42, N°3; May 2003 , Houston Veterans Affairs Medical Center; Baylor College of Medicine Of Houston , 2003

Nawwar Al Attar, Claire Carrion, Said Ghostine, Isabelle Garcin, Jean-Thomas Vilquin, Albert A. Hagège and Philippe Menasché, Long-term (1 year) functional and histological results of autologous skeletal muscle cells transplantation in rat (318.09 Ko), Cardiovascular Research 2003 58(1):142-148, Department of Cardiovascular Surgery and INSERM U 572, Hôpital Européen Georges Pompidou, 20, rue Leblanc, 75015 Paris, Cedex, France INSERM U 523, Institut de Myologie, Hôpital Pitié-Salpêtrière, Paris, France Department of Cardiology, Hôpital Européen Georges Pompidou and Faculté de Médecine Necker-Paris V, Paris, France, 2002

application : telemetry (implantable)

top of page

Gregory T. Jones, PhD, Mark W. Grant, MBBS, Ian A. Thomson, MBChB, FRACS, B. Geraldine Hill, BSc, DMU, and André M. van Rij, MD, FRACS, Characterization of a porcine model of chronic superficial varicose veins (1.33 Mo), Society for Vascular Surgery- J Vasc Surg 2009;49:1554-61, Vascular Research Group, Surgery Department, University of Otago, 2009

M Lim1, D McCormick2, R Kirton1,3, D Budgett1,3, M Kondo1, W Pallas1, S Guild3, C Barrett3, S Malpas3,1, A new implantable transmitter for simultaneous recording of sympathetic nerve activity and blood pressure (136.31 Ko), -, 1 Telemetry Research Limited, PO Box 5504, Auckland, New Zealand, 2 Auckland Bioengineering Institute, 3-Department of Physiology, The University of Auckland, New Zealand, 2008

S. Malpas1,2, M. Lim1, D McCormick2, R Kirton1, B Van Vliet3, A Easteal, C Barrett2, S Guild2, M. Pinkham2, D Budgett1,2., A novel implantable blood pressure telemetry device; Comparison between Data Sciences and Telemetry Research systems. (236.55 Ko), -, Telemetry Research Ltd 1 & University of Auckland 2, New Zealand & Memorial University 3, St Johns, Canada, 2008

Bruce N. Van Vliet1, Sarah-Jane Guild2, Carolyn Barrett2, Fiona McBryde2 and Simon Malpas2, Long-term recording of renal sympathetic nerve activity in conscious rats via telemetry (3.79 Mo), The FASEB Journal. 2008;22:738.10., 1 Faculty of Medicine, Memorial University of Newfoundland, St. John’s, Canada 2 Department of Physiology, University of Auckland, Auckland, New Zealand, 2008

Sarah-Jane Guild,1 Carolyn J. Barrett,1 Fiona D. McBryde,1 Bruce N. Van Vliet,2 and Simon C. Malpas1,3, Sampling of cardiovascular data; how often and how much? (569.25 Ko), Am J Physiol Regul Integr Comp Physiol 295: R510–R515, 2008., 1Circulatory Control Laboratory, Department of Physiology and Bioengineering Institute, University of Auckland, Auckland; 2 BioMedical Sciences Division, Memorial University of Newfoundland, Canada; and 3 Telemetry Research Ltd, Auckland, New Zealand, 2008

Lindsea C. Booth, Laura Bennet, Carolyn J. Barrett, Sarah-Jane Guild, Guido Wassink, Alistair J. Gunn, and Simon C. Malpas, Cardiac-related rhythms in sympathetic nerve activity in preterm fetal sheep (313.12 Ko), Am J Physiol Regul Integr Comp Physiol 293: R185–R190, Fetal Physiology and Neuroscience Group and Circulatory Control Laboratory, Department of Physiology, University of Auckland, Auckland, New Zealand, 2007

David M. Budgett,1 Aiguo Patrick Hu,2 Ping Si,2 Wayne T. Pallas,1 Mark G. Donnelly,1 Jared W. T. Broad,1 Carolyn J. Barrett,3 Sarah-Jane Guild,3 and Simon C. Malpas1,3, Novel technology for the provision of power to implantable physiological devices (129.66 Ko), American Physiological Society - J Appl Physiol 102: 1658–1663, 2007., 1Bioengineering Institute and 2Department of Electrical and Computer Engineering and 3Department of Physiology, University of Auckland, Auckland, New Zealand, 2007

Simon C. Malpas, Rohit Ramchandra, Sarah-Jane Guild, David M. Budgett, and Carolyn J. Barrett, Baroreflex mechanisms regulating mean level of SNA differ from those regulating the timing and entrainment of the sympathetic discharges in rabbits (794.39 Ko), Am J Physiol Regul Integr Comp Physiol 291: R400–R409, 2006., Circulatory Control Laboratory, Department of Physiology and Bioengineering Institute, University of Auckland, Auckland, New Zealand, 2006

Carolyn J. Barrett, Sarah-Jane Guild, Rohit Ramchandra, Simon C. Malpas, Baroreceptor Denervation Prevents Sympathoinhibition During Angiotensin II–Induced Hypertension (317.88 Ko), Hypertension. 2005;46:168-172, Circulatory Control Laboratory, Department of Physiology, University of Auckland, New Zealand, 2005

Lisa R. Leon, Larry D. Walker, David A. DuBose, and Lou A. Stephenson, Biotelemetry transmitter implantation in rodents: impact on growth and circadian rhythms (576.67 Ko), Am J Physiol Regul Integr Comp Physiol 286: R967–R974, 2004., United States Army Research Institute of Environmental Medicine, Thermal and Mountain Medicine Division, Natick, Massachusetts, 2004

Carolyn J. Barrett, Rohit Ramchandra, Sarah-Jane Guild, Aneela Lala, David M. Budgett, Simon C. Malpas, What Sets the Long-Term Level of Renal Sympathetic Nerve Activity A Role for Angiotensin II and Baroreflexes? (124.87 Ko), Circulation Research 2003;92:1330-1336, Circulatory Control Laboratory, Department of Physiology, University of Auckland, New Zealand - American Heart Association, Inc., 2003

M. M. Moran 1, R. R. Roy 2, C. E. Wade 3, B. J. Corbin 3, and R. E. Grindeland 3, Size constraints of telemeters in rats (144.85 Ko), J Appl Physiol 85:1564-1571, 1998., 1G. B. Tech, Houston, Texas 77258; 2Brain Research Institute, University of California, Los Angeles 90095-1761; and 3Life Sciences Research Division, National Aeronautics and Space Administration-Ames Research Center, Moffett Field, California 94035, 1998

Simon C. Malpas, The rhythmicity of sympathetic nerve activity (1.04 Mo), Progress in Neurobiology Vol. 56, pp. 65 to 96, 1998, Department of Physiology, Auckland University, 1998

ANDREA SGOIFO,* DONATELLA STILLI,* DANTE MEDICI,~ PAOLA GALLO,* BEATRICE AIMI* AND EZIO MUSSO*l, Electrode Positioning for Reliable Telemetry ECG Recordings During Social Stress in Unrestrained Rats (545.75 Ko), Physiology & Behavior, Vol. 60, No. 6, pp. 1397-1401, 1996, *Dipartimerrto di Biologia Evolutiva e Funzionale, Sezione Fisiologia, University di Parma, viale delle Scienze, 43100 Parma, Italy and fCattedra di Chirurgia del Cuore e dei Grossi Vasi, Ospedale di Parma, via A. Gramsci 14, 43100 Parma, Italy, 1996

application : telemetry (noninvasive)

top of page

Anne-Marie Betat, Jean-Gerard Napoleoni, Guillaume Froget, Alain Simonnard, Non-invasive blood pressure monitoring in ambulatory beagle dogs (1.33 Mo), Poster presentation at the 9th Annual Meeting of the Safety Pharmacology Society (SPS), Strasbourg, France., CIT, Evreux, FRANCE & emka TECHNOLOGIES, Paris, FRANCE , 2009

Breidenbach, Alexander; Festag, Matthias; Greiter-Wilke, Andrea; Holzgrefe, Henry; Schmitt, Georg; Weiser, Thomas, Sensitivity of telemetry to predict QT interval prolongation in dog toxicity studies: assessment of the effects of moxifloxacin by invasive and non-invasive methods. (216.25 Ko), Society of Toxicology meeting, Baltimore, MD, March 2009, Non Clinical Drug Safety, F. Hoffmann-La Roche, Basel, Switzerland, 2009

Hai Ming Tang, Alvie Bello, Chris Lawson, Bluegrass Biggs, Vicki Garcia, Sushmita Chanda, Kyle Kolaja, Stefan Platz, Christina Riordan, and Dinah Misner, Comparisons of emka TECHNOLOGIES Jacket System and DSI Implant in Conscious Dogs with Moxifloxacin (522.98 Ko), SPS Scientific Poster Presentation, Roche, 2008

Aidan K. Curran 1, Josh Burton 2, Susan Skeans1, Devon Landers1, Shannon OBrien 2 and Richard W. Chapman 1., Continuous measures of breathing and phase angle in conscious cynomolgus monkeys. (352.38 Ko), Schering-Plough Research Institute - Poster presentation at Experimental Biology 2008, 1Pulmonary and Peripheral Neurobiology, Schering-Plough Research Institute, 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA and 2emka TECHNOLOGIES Inc., Falls Church VA 22046, USA, 2008

Ward G, Milliken P, Parr L, Bester R, Patel B, McMahon N., Non-Invasive Telemetry for Monitoring ECG in Singly and Group Housed Dogs—The Effect of Moxifloxacin Administration (2.81 Mo), SPS Scientific Poster Presentation, Safety Pharmacology, GlaxoSmithKline, The Frythe, Welwyn, Hertfordshire, UK, 2008

Anne-Marie Betat, Aurelie Baleydier, Guillaume Froget, Pierre Lainee, Roy Forster, and Jean-Francois Le Bigot, External telemetry investigation of ecg parameters for group housed non-rodent toxicology studies, Toxicology Letters Volume 164, Supplement 1, 20 September 2006, Pages S308-S309 Abstracts of the EUROTOX 2006/6 CTDC Congress - 43rd Congress of the European Societies of Toxicology & 6th Congress of Toxicology in Developing Countries, CIT, Evreux, France, 2006

K. Moyser, J. Schofield, D. Simpson, D. Hunter, Benefits and limitations of an external telemetry system on canine toxicity studies (328.44 Ko), Animal Technology and Welfare, April 2004, AstraZeneca UK Ltd, 2004

Derek Hunter; Jason Schofield; Katy Gracie; Jackie Moors; Karen Philp; Helen Prior; Jean-Pierre Valentin; Tim Hammond, Comparison of Non-Invasive versus Invasive Telemetry (60.94 Ko), Poster, AstraZeneca UK Ltd, 2003

Adam R Schoell, DVM, Emily R Robinson, DVM&Anne L Fitzerald, Improved methods for electrocardiogram monitoring in ambulatory dogs (845.22 Ko), Poster, PGRD Ann Arbor Laboratories, Pfizer Inc, 2003

Derek Hunter; Jason Schofield; Katy Gracie; Jackie Moors; Karen Philp; Paul Carter; Helen Prior; Jean-Pierre Valentin; Tim Hammond, Use of a non-invasive telemetry system (emka) for functional cardiovascular endpoints in toxicology studies (54.77 Ko), Poster, AstraZeneca UK Ltd, 2003