After myocardial infarction, the heart fails to regenerate and ischemic/reperfusion injury leads to cardiomyocyte loss and fibrosis leading to impaired heart function. The medical treatment for heart failure, for the most part, is not disease modifying, it’s simply symptomatic. Another strategy is to address the fundamental issue of a failing heart, which is the loss of cardiomyocytes after a heart attack.
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, scientists from leading preclinical contract organizations (CROs) discussed how traditional IND-enabling studies involving primates and dogs can be complemented (and sometimes even replaced) by alternative models such as mice, rats, rabbits and pigs.
The use of “super-intervals” improves statistical sensitivity to detect QTc interval prolongation and thus allows to get more robust QTc datasets with reduced signal variability.
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
In recent years, electronic cigarettes have become rapidly popular worldwide, despite growing evidence that they adversely impact cardiopulmonary health.
Further scientific evidence is needed to clarify the risks of e-cigarettes and guide the use and regulation of these nicotine aerosol delivery devices.
All research model systems have unique strengths and challenges regarding the generalizability of data to other systems. Pre-clinical researchers attempt to describe and interact with human clinical phenotypes using animal models.
Septic shock is a systemic inflammatory response to an infection leading to both cardiovascular dysfunction and cellular metabolic alterations.
In 2017, Marine Ferron et al investigated cardiac changes associated with sepsis, specifically intrinsic contractility and myocardial responses.
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