Implanted telemetry is established as the gold standard for preclinical Drug Development, Safety Pharmacology and Toxicology studies. Let’s understand how it evolved in the last decade and what are the current challenges faced by scientists.
A recent study led by Decan Jiang et al, has shed light on how porcine models are helping surgical training—particularly in the complex field of kidney transplantation.
In recent years, the gut microbiome has emerged as a powerful influencer of cardiovascular health. The concept of the gut-heart axis—the bidirectional communication between gut microbes and the cardiovascular system—is no longer speculative, although there is still much to discover and many challenges to overcome.
The Food and Drug Administration’s (FDA) recent Roadmap to Reducing Animal Testing in Preclinical Safety Studies marks a pivotal shift toward the adoption of innovative, human-relevant methodologies commonly known as New Approach Methodologies (NAMs).
This article presents a refined, minimally invasive ovine model of ischaemia–reperfusion–infarction which incorporates implantable defibrillators and addresses many limitations seen in previous approaches, enhancing the safety, reproducibility, and clinical relevance of preclinical cardiac research.
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints.
For ground squirrels, anorexia is not a pathological condition but an adaptive strategy for survival during hibernation. Recent research by Sarah M. Mohr et al highlights the unique hibernation patterns of thirteen-lined ground squirrels, which could provide valuable insights into anorexia in humans.
Sudden Unexpected Death in Epilepsy (SUDEP) remains a critical concern in epilepsy management, with the underlying mechanisms still not fully understood.
The University of Guelph researchers studied how a diet high in soluble fibers affected sled dogs’ physiological parameters.
To track respiratory rate and body temperature while the dogs were running, they used the emkaPACK jacketed telemetry system.
Despites international treaties, the usage of chemical weapons is still a concern nowadays. This article highlights a study using Dual-chamber plethysmography for the determination of the NOAEL dose of an oxime, for the treatment of organophosphorus-nerve agents poisoning.
Learn about Heart Failure with Preserved Ejection Fraction and the development of large animal models for studying and testing therapies for this complex condition.
Because of the multifactorial nature of cardiovascular diseases, there is not a single specie which is optimal for all studies. The choice of an animal model should be carefully made as it can affect the experimental outcomes and the reasonable translation of study findings to humans.
To develop safe and effective cancer therapies, it is crucial to understand chemotherapy-induced cardiotoxicity and cancer‐related cardiac complications. This blog highlights recent discoveries in this field.
After myocardial infarction, the heart fails to regenerate and ischemic/reperfusion injury leads to cardiomyocyte loss and fibrosis leading to impaired heart function. The medical treatment for heart failure, for the most part, is not disease modifying, it’s simply symptomatic. Another strategy is to address the fundamental issue of a failing heart, which is the loss of cardiomyocytes after a heart attack.
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, scientists from leading preclinical contract organizations (CROs) discussed how traditional IND-enabling studies involving primates and dogs can be complemented (and sometimes even replaced) by alternative models such as mice, rats, rabbits and pigs.
The use of “super-intervals” improves statistical sensitivity to detect QTc interval prolongation and thus allows to get more robust QTc datasets with reduced signal variability.
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
In the intricate web of neural circuits that guide our every move, a recent study has shed light on a fascinating phenomenon: the arrest of ongoing movements.
In recent years, electronic cigarettes have become rapidly popular worldwide, despite growing evidence that they adversely impact cardiopulmonary health.
Further scientific evidence is needed to clarify the risks of e-cigarettes and guide the use and regulation of these nicotine aerosol delivery devices.
All research model systems have unique strengths and challenges regarding the generalizability of data to other systems. Pre-clinical researchers attempt to describe and interact with human clinical phenotypes using animal models.
Implanted telemetry is established as the gold standard for preclinical Drug Development, Safety Pharmacology and Toxicology studies. Let’s understand how it evolved in the last decade and what are the current challenges faced by scientists.
Wireless telemetry has been used for several years on cows, sheep, pigs or horses. Discover some concreate applications.
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