Seizure is a disorder of the nervous system, thought to be the result of faulty electrical activity in the brain which can lead to changes in behavior, movement, feelings, and/or levels of consciousness.
Epilepsy studies involve seizure detection from EEG traces, however other parameters can be of interest, such as ECG, EMG or activity/behavior. For instance, researches have been suggesting that SUDEP (Sudden Unexpected Death in Epilepsy) could occur preferentially during sleep. Therefore, combining epilepsy and sleep analysis, through a unique analysis software, is a crucial advantage when studying SUDEP and other comorbidities.
Additionally, seizure detection can be useful when working in toxicology or safety pharmacology studies. The testing of various agents and drugs and their effects on seizure threshold or the induction of seizures can be useful when determining safety of said compounds and therapeutics.
Video monitoring, combined with biopotentials acquisition, is also recommended, to identify and characterize seizure movements and give insight to seizure development and intensity. EEG and synchronized video acquisition help to identify motor and non-motor seizures or behavioral artifacts.
Wireless technology permits a constant transfer of high volumes of digital data from freely moving animals. The advantages associated with this technique are well established; higher quality data obtained from naturally behaving subjects, which reliably captures detailed physiological events.