Seizure is a disorder of the nervous system, thought to be the result of faulty electrical activity in the brain which can lead to changes in behavior, movement, feelings, and/or levels of consciousness.
Epilepsy studies involve seizure detection from EEG traces, however other parameters can be of interest, such as ECG, EMG or activity/behavior. For instance, researches have been suggesting that SUDEP (Sudden Unexpected Death in Epilepsy) could occur preferentially during sleep. Therefore, combining epilepsy and sleep analysis, through a unique analysis software, is a crucial advantage when studying SUDEP and other comorbidities.
Additionally, seizure detection can be useful when working in toxicology or safety pharmacology studies. The testing of various agents and drugs and their effects on seizure threshold or the induction of seizures can be useful when determining safety of said compounds and therapeutics.
Video monitoring, combined with biopotentials acquisition, is also recommended, to identify and characterize seizure movements and give insight to seizure development and intensity. EEG and synchronized video acquisition help to identify motor and non-motor seizures or behavioral artifacts.
Wireless technology permits a constant transfer of high volumes of digital data from freely moving animals. The advantages associated with this technique are well established; higher quality data obtained from naturally behaving subjects, which reliably captures detailed physiological events.
Various sized options are available in our implantable telemetry systems.
Fully implantable easyTEL+ system allow subjects to freely move around their cages with group housing options.
In rodents, it acquires a single biopotential and provides the options for activity and core body temperature recordings.
In large animals, it offers up to 4 biopotentials (EEG, EOG, ECG, EMG) with optional temperature and activity monitoring that can be paired with synchronized video recording.
The easyTEL+RP reusable telemeter acquires up to four low-noise biopotentials (cortical or penetrating EEG, EMG, ECG, EOG) as well as activity from rodents 200g or more.Â
In large animals, it collects neurological and activity changes without surgical implantation of the telemeter. Subjects are equipped with an external transmitter housed in a jacket or a helmet with surface leads paced on the scalp.
Externalized transmitters can be reused across subjects, cohorts, and studies, reducing start-up costs for behavioral studies requiring a large subject pool. The custom design of our transmitters (electrodes, electrode wires, polarity) combined with user configurable sampling rate, resolution, and gain, provide users with various study design options. Easily exchangeable batteries last for up to 150 hours of continuous recordings.
Our powerful EEG analysis software helps researchers comb through the data and analyze their subject’s response to various agents, drugs, and disease models. It allows the analysis of EEG morphology with time-synchronized video for behavioral verification.
SLEEP SCORING
Automated sleep scoring allows for further behavioral analysis through sleep staging that can be overlaid on signal screen. FFT spectral information can also be overlaid on the signal screen to observe changes between epoch in relation to other variables.
EPILEPSY DETECTION MODULE
From the EEG signal, the seizure detection module automatically detects seizures, and combines multiple user adjusted criteria and logical modes to produce the following:
Valid seizures can be exported to text or xls files.
Heatmaps allow for easy identification of changes in signal over time or across leads and related to disease, activity, or incoherence across various leads or brain regions.
Dr. Poulsen was an incredible researcher, collaborator and friend to all of us at emka.
He worked in the Neurosurgery Department, in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo. His research focus was the post-traumatic epilepsy and potential induced seizures.
Dr. Poulsen shared his thoughts about his work during an interview in 2020.
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Researchers will receive an email report showing emka TECHNOLOGIES publications relevant to their specific application research area, along with custom equipment recommendations and commentary.
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