Resources

Leveraging Telemetry to Expand Beyond the Standard Endpoints

At the 2026 Society of Toxicology Annual Meeting, we hosted a scientific session highlighting how to unlock hidden insigths.
William Salvail (IPS Therapeutique Inc.) presented how his team is validating the emka easyTEL+ digital telemetry implant for biopotentials and blood pressure measurement in mice, while Dr. Beth Geist and Dr. Daniel Edelberg (Kardigan) presented their initial experiences leveraging the easyTEL+ telemetry system on rats.

Advanced EEG Telemetry Measurements in Mice

Presented at the 2025 Neuroscience conference in San Diego, this poster presents applications for seizure phenotyping, quantitative EEG and sleep architecture, using easyTEL+S digital telemetry on mice.

Implanted Rodent Telemetry

During our 2025 SOT seminar, William Salvail (IPS Therapeutique Inc) discussed the benefits of implanted digital telemetry to improve the clinical relevance of non-clinical efficacy and toxicity testing, while Dr. Monica Metea (Preclinical Electrophysiology Consulting, LLC) presented advanced methods for streamlining telemetry electrophysiology analytics.

Large animal models of heart failure

SCIREQ & emka Technologies hosted a webinar on Large Animal Models for Preclinical Studies of Heart Failure, with Dr. Moctezuma-Ramirez from the Texas Heart Institute. Dr. Moctezuma-Ramirez presented the development of their percutaneous myocardial infarction model in pigs, designed to mimic human heart failure with reduced ejection fraction (HFrEF).

Cardiac and Pulmonary monitoring without Bands

During the 2024 Safety Pharmacology Society (SPS) Conference in San Diego, Ken Kearney (Charles River Laboratories) shared the results of a study, evaluating the ability of our jacketed external telemetry system to capture ECG and respiratory data simultaneously, from ECG leads.

COVID-19 studies with emkaPACK

This application note reviews the significant contributions of emkaPACK in the research and development of Olgotrelvir, the ZF2001 vaccine, and nebulized SARS-CoV-2 neutralizing antibodies.

Investigating Arrhythmias using ecgAUTO software

In this application note, we explore a few studies conducted in 2024 and using ecgAUTO software for automated ECG data analysis, aiming to enhance our understanding of arrhythmias and develop targeted interventions.

Taking advantage of new models and tools to rethink efficacy and Safety Research

During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, Dr. Dany Salvail (IPST, QC, Canada) explained how experienced pharmacologists rely on alternate models combined with sophisticated measurement techniques that go well beyond the ICH guidelines to help sponsors truly understand and quantify liabilities associated with their lead compounds early on.

Swine, the other tox species

During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, Dr. Donald Hodges (CBSET, MA, USA) outlined how proven translational characteristics and historical data are enabling the wider adoption of swine as an alternative to dogs and Non-Human Primates in the context of shortages and rising costs.

Use of the rat in cardiovascular screening assays

During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, Dr. Michael Stonerook (AmplifyBio, OH, USA) highlighted the benefits and limitations of the rat model for cardiovascular screening assays.

Accurately Phenotyping Arrhythmia in rodents

Finding arrhythmias in rodents can be tedious, thrilling, and controversial. During the 2023 Society of Toxicology (SOT) conference in Nashville, Dr. Alex Carll discussed rodent ECG morphology and physiologic vs. pathologic arrhythmias in mice and rats.

Mitigating transient arrhythmogenicity in pig following human cardiomyocyte transplantation

To achieve therapeutic cardiac regeneration, the University of Washington Medicine Heart Regeneration Program has been focusing on remuscularization with genuine cardiomyocytes derived from pluripotent stem-cells.

Vascular function study using a myograph

Myographs are used to determine the myogenic tone, evaluate the impact of treatment on Vascular Smooth Muscle Cells contractility and study endothelial function.

Preclinical Blood Pressure Measurements

In our SPS 2022 hosted session, we discussed the Translational Assessment of Pressor Effects of Drugs with Dr.Christine Garnett (FDA), Dr.Todd Wisialowski (Pfizer) and Dr.Brian Roche (Charles River).

E-cigarettes induce Cardiac Arrhythmia and Conduction Defects In Mice

This document provides a summary of the study by Dr. Carll et al. at the University of Louisville published in Nature Communications.

Case study – A rat model of long-term deficit following severe traumatic brain injury

The ECG monitoring of exercise in Wistar rats following Traumatic Brain Injury offers insight into possible autonomic dysregulation. This case study highlights the ability to simultaneously record ECG in subjects exercising in an open pool.

The Importance of Group Housing for Telemetry Studies.

This document provides an overview of the numerous benefits of group housing during preclinical Drug Development, Safety Pharmacology and Toxicology studies.

Case study – A dual implantation for combined Neuro and Cardiovascular recording in dog.

Digital telemetry offers the ability to implant two transmitters in large animals, allowing to simultaneously record a large number of physiological parameters in a single subject. This case study highlights an experiment conducted by safety pharmacology team at Charles River Montreal, to combine seizure and cardiovascular liability assessment.

Understanding Pattern Recognition

This document provides an overview of ecgAUTO’s analysis methodologies and capabilities for preclinical cardiovascular research, including ECG Interval and Arrhythmia analysis.

Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment

This presentation given by Simon Authier, DVM, MBA, PhD, DSP Deputy Chief Scientific Officer at CitoxLab North America in 2019, compares well established ECG analysis methods used in toxicology with novel strategies that may offer lower false positive rates.