Parkinson’s disease (PD) is a neurodegenerative condition that primarily affects movement control. It occurs with neurodegeneration in the dopaminergic pathways of the brain, particularly in the basal ganglia and motor cortex.
Researchers rely on various animal models to study Parkinson’s disease, which are essential for testing new treatments and understanding the progression of the disease. These models include rodents and non-human primates, such as macaques, which closely mimic human PD symptoms.
Real-time monitoring of animal behavior and physiology is critical in Parkinson’s disease research, as motor symptoms are central to the condition.
Our easyTEL+ digital telemetry systems enable seamless, wireless monitoring of physiological endpoints in animal models of Parkinson’s Disease.
Managing up to 32 single or group-housed subjects with optional synchronized video for comprehensive behavioral analysis, it enables real-time data collection of:
Transmitter state (on/sleep) and reconfigurable settings (sampling rate, resolution, transmission power, transmission frequency, etc.) can be controlled wirelessly. This reduces human interaction, thereby increasing the likelihood or the animal’s natural state during behavioral testing.
In large animals, easyTEL+ implant are able to record respiration by impedance. PD is known to impact the autonomic nervous system, which also controls respiratory function. Abnormalities in breathing patterns such as bradypnea (slow breathing), hypoventilation, and irregular breathing have been observed in PD patients, particularly during sleep. Preclinical studies that measure respiratory patterns can help identify early autonomic dysfunction and potential respiratory-related complications, such as sleep-disordered breathing or aspiration pneumonia.
The easyTEL+RP uses external telemeters that can be reused across subjects, cohorts, and studies, reducing start-up costs for behavioral studies requiring a large subject pool. The custom design of our transmitters (electrodes, electrode wires, polarity) combined with user configurable sampling rate, resolution, and gain, provide users with various study design options. Easily exchangeable batteries last for up to 150 hours of continuous recordings.
In rodents (from 200g), easyTEL+RP acquires up to four low-noise biopotentials (cortical or penetrating EEG, EMG, ECG, EOG) as well as activity .
In large animals, it collects neurological and activity changes without surgical implantation of the telemeter. Subjects are equipped with an external transmitter housed in a jacket or a helmet with surface leads paced on the scalp.
Whole body plethysmography permits a continuous and non-invasive assessment of breathing patterns in conscious subjects. Measurements of respiratory rate, estimated tidal volume, minute ventilation and events like apneas and deep sighs provide valuable insights into the subject’s breathing drive and behavior. Plethysmography provides the ideal approach to assess abnormalities in breathing patterns.
Whole body plethysmography and digital telemetry can be combined on a synchronized platform, for concurrent analysis of respiratory and cardiovascular and neurological data.
Flexivent is used in preclinical Parkinson’s disease research to assess lung function and respiratory parameters in animal models. Flexivent can help quantify how PD impacts lung mechanics, airway resistance, and respiratory patterns. Additionally, it can be used to test potential therapeutic interventions or drug candidates aimed at improving respiratory health in Parkinson’s models, which can contribute to a better understanding of the disease’s impact on the body.
The flexiVent’s exhaustive set of highly reproducible measurements offers outcomes that can be trusted at any point during the preclinical drug development process.
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