Cardiopulmonary Impact of Wildfire Smoke
As global temperatures rise, wildfires are increasingly recognized as major public health crises. Exposure to wildfire smoke is known to worsen respiratory diseases such as asthma and chronic obstructive pulmonary disease (COPD).
Respiratory Monitoring in Preclinical Research without restraint or acclimation
In preclinical respiratory studies, traditional methods like plethysmography often require animal restraint and extensive acclimation, limiting their ability to capture dynamic respiratory changes.
To overcome these challenges, IPS Therapeutique Inc. validated a novel telemetry-based technique for continuous monitoring of intrapleural pressure and respiratory patterns in conscious, freely moving rats.
How Pigs Are Helping Surgeons Perfect Kidney Surgery
A recent study led by Decan Jiang et al, has shed light on how porcine models are helping surgical training—particularly in the complex field of kidney transplantation.
Gut-Heart Axis
In recent years, the gut microbiome has emerged as a powerful influencer of cardiovascular health. The concept of the gut-heart axis—the bidirectional communication between gut microbes and the cardiovascular system—is no longer speculative, although there is still much to discover and many challenges to overcome.
Navigating the Future of Preclinical Research: Aligning with the FDA’s Roadmap on Animal Testing
The Food and Drug Administration’s (FDA) recent Roadmap to Reducing Animal Testing in Preclinical Safety Studies marks a pivotal shift toward the adoption of innovative, human-relevant methodologies commonly known as New Approach Methodologies (NAMs).
Refining the Study of Myocardial Infarction in Sheep
This article presents a refined, minimally invasive ovine model of ischaemia–reperfusion–infarction which incorporates implantable defibrillators and addresses many limitations seen in previous approaches, enhancing the safety, reproducibility, and clinical relevance of preclinical cardiac research.
The challenge of cardiovascular toxicity evaluation
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints.
Understanding Anorexia Through the Study of Ground Squirrels During Hibernation
For ground squirrels, anorexia is not a pathological condition but an adaptive strategy for survival during hibernation. Recent research by Sarah M. Mohr et al highlights the unique hibernation patterns of thirteen-lined ground squirrels, which could provide valuable insights into anorexia in humans.
The Role of Orexin Neurons in Altered Respiratory Responses and SUDEP Risk
Sudden Unexpected Death in Epilepsy (SUDEP) remains a critical concern in epilepsy management, with the underlying mechanisms still not fully understood.
Measuring body temperature and respiration in running sled dogs
The University of Guelph researchers studied how a diet high in soluble fibers affected sled dogs’ physiological parameters.
To track respiratory rate and body temperature while the dogs were running, they used the emkaPACK jacketed telemetry system.
