Rats for cardiovascular research
Because of the multifactorial nature of cardiovascular diseases, there is not a single specie which is optimal for all studies. The choice of an animal model should be carefully made as it can affect the experimental outcomes and the reasonable translation of study findings to humans.
Cancer and Chemotherapy-induced Cardiotoxicity
To develop safe and effective cancer therapies, it is crucial to understand chemotherapy-induced cardiotoxicity and cancer‐related cardiac complications. This blog highlights recent discoveries in this field.
Cell-based & cell-free therapies for myocardial infarction
After myocardial infarction, the heart fails to regenerate and ischemic/reperfusion injury leads to cardiomyocyte loss and fibrosis leading to impaired heart function. The medical treatment for heart failure, for the most part, is not disease modifying, it’s simply symptomatic. Another strategy is to address the fundamental issue of a failing heart, which is the loss of cardiomyocytes after a heart attack.
Maximizing Insights from Preclinical Safety Studies in the context of rising costs and shortages
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, scientists from leading preclinical contract organizations (CROs) discussed how traditional IND-enabling studies involving primates and dogs can be complemented (and sometimes even replaced) by alternative models such as mice, rats, rabbits and pigs.
Gastrointestinal motility
The evaluation of the gastrointestinal (GI) motility is useful to detect pathological conditions of the GI system, the therapeutic potential of drugs in motility disorders or potential drug side effects on motility or inflammation.
Integrating SEND outcomes
As an industry partner with deep expertise in IND-enabling studies, emka TECHNOLOGIES helps nonclinical scientists comply with SEND requirements by generating SEND 3.1 compatible tables directly from emka TECHNOLOGIES software.
Studying cardiac dysfunction in septic shock in rat’s isolated perfused heart
Septic shock is a systemic inflammatory response to an infection leading to both cardiovascular dysfunction and cellular metabolic alterations.
In 2017, Marine Ferron et al investigated cardiac changes associated with sepsis, specifically intrinsic contractility and myocardial responses.