Implanted Rodent Telemetry
During our 2025 SOT seminar, William Salvail (IPS Therapeutique Inc) discussed the benefits of implanted digital telemetry to improve the clinical relevance of non-clinical efficacy and toxicity testing, while Dr. Monica Metea (Preclinical Electrophysiology Consulting, LLC) presented advanced methods for streamlining telemetry electrophysiology analytics.
Swine, the other tox species
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, Dr. Donald Hodges (CBSET, MA, USA) outlined how proven translational characteristics and historical data are enabling the wider adoption of swine as an alternative to dogs and Non-Human Primates in the context of shortages and rising costs.
The Importance of Group Housing for Telemetry Studies.
This document provides an overview of the numerous benefits of group housing during preclinical Drug Development, Safety Pharmacology and Toxicology studies.
Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment
This presentation given by Simon Authier, DVM, MBA, PhD, DSP Deputy Chief Scientific Officer at CitoxLab North America in 2019, compares well established ECG analysis methods used in toxicology with novel strategies that may offer lower false positive rates.
Cardiotoxicity
Cardiotoxicity studies Cardiotoxicity refers to damage or dysfunction of the heart caused by exposure to drugs, environmental pollutants, or other toxic agents. It is a critical concern in drug development and environmental health, often leading to heart failure, arrhythmias, and electrophysiological abnormalities. Functional cardiovascular outcomes such as electrocardiograms (ECGs), blood pressure, and other hemodynamic endpoints can offer powerful insights […]
Toxicology
Preclinical Toxicology studies Preclinical toxicology investigates the adverse effects of test articles (e.g. drugs, toxins, and other agents) on various model systems to evaluate clinical risk. Preclinical toxicology integrates many disciplines to investigate a compound’s safety profile, including genotoxicity, mutagenicity, repeat-dose cardiotoxicity, neurotoxicity, and general toxicology. In the United States, toxicology studies are regulated by […]
