Swine, the other tox species
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, Dr. Donald Hodges (CBSET, MA, USA) outlined how proven translational characteristics and historical data are enabling the wider adoption of swine as an alternative to dogs and Non-Human Primates in the context of shortages and rising costs.
Cardiotoxicity
Cardiotoxicity studies Cardiotoxicity can be described as dysfunction of the heart stemming from exposure to drugs, pollutants, or other toxins. The irreversible cardiac dysfunction and development of heart failure is characterized by electrophysiological, morphological, and biochemical alterations. Cardiotoxicity is often associated with a decline in left ventricular ejection fraction (LVEF) and autonomic disbalance. Drug-induced cardiotoxicity […]
Toxicology
Preclinical Toxicology studies Preclinical toxicology investigates the adverse effects of test articles (e.g. drugs, toxins, and other agents) on various model systems to evaluate clinical risk. Preclinical toxicology integrates many disciplines to investigate a compound’s safety profile, including genotoxicity, mutagenicity, repeat-dose cardiotoxicity, neurotoxicity, and general toxicology. In the United States, toxicology studies are regulated by […]
