We will be exhibiting our solutions for toxicology studies. With no more pesky wires, a mobile acquisition station, paperless recordings, automated batch analysis, and GLP compliance and/or SEND reporting, our solutions allow you to work smarter.
Snapshot-ECG recordings are the mainstay of cardiovascular toxicity studies owing to their cost-effectiveness and vast amount of reference data. The emkaPACK5 can be configured in a mobile snapshot ECG recording system, where the receiver and PC are wheeled into the subject room for maximum efficiency and flexibility. The mobile system is used in combination with the emkaPACK4G transmitter to obtain snapshot ECG measurements.
emkaPACK4G Jacketed Telemetry
In a jacketed telemetry study, large animals (canine, primate, swine, sheep, other) are equipped with custom-designed clothing and instrumented with the emkaPACK5 transmitter, which wirelessly transmits physiological signals from the ambulatory subjects.
Jacketed telemetry is often considered more sensitive and reproducible than traditional “snapshot” recordings in restrained animals.
An easyTEL+ M2 implant can be added for the acquisition of minimally invasive blood pressure and core temperature. Uniquely adapted to toxicology studies, this implant equipped with a 2F or 4.5F pressure catheter, is intended for subcutaneous placement in small primates or other large animal models.
rodentPACK Jacketed Telemetry
rodentPACK non-invasive external telemetry eliminates the need for anaesthesia and surgery in rats studies, while achieving high-quality translational physiological outcomes.
Using wireless telemetry, confounding effects such as increased stress and mortality are avoided, allowing compliance with the 3R’s principles (Replacement, Reduction, Refinement).
Non-invasive plethysmography techniques such as whole body plethysmography (WBP), double chamber plethysmography (DCP), or head-out plethysmography (HOP) can be used in exploratory toxicology studies to asses the toxicity risk of a candidate drug in conscious animals. This technique provides essential physiological information related to changes in respiratory function measurements such as tidal volume (Vt), respiratory rate (RR) and minute ventilation (MV).
Airway obstruction is one of the leading respiratory difficulties encountered during clinical trials of a drug candidate and although these techniques provide the advantage of assessment of respiratory function measurements, independent of anaesthetic side effects, the drawback is that these techniques do not provide information related to lung mechanics such as airway resistance.
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