Traditional safety pharmacology and toxicology studies often rely on a limited set of endpoints, potentially overlooking subtle physiological changes that could inform compound safety profiles.
This session explores how integrating emkaPACK non-invasive and easyTEL+ implantable telemetry technologies expand the scope of safety assessments.
Leveraging Novel Telemetry for Advanced Hemodynamic Characterization in Murine Models – Validating Wireless Pressure Monitoring for Pre-Clinical Safety Pharmacology
Session Outline: This session will explore the transition toward high-fidelity, continuous telemetry in murine models, focusing on the interplay between autonomic plasticity and the biological limits of cardiac performance. By moving beyond simple heart rate and blood pressure observations, we explore the “Kinetic Ceiling” of naïve mice: The point at which chronotropy begins to compromise ventricular filling and stroke volume efficiency. Through a series of multi-factorial challenges, including the mapping of baroreflex sensitivity and the assessment of circadian dipping architecture, we also demonstrate how telemetry data acquisition, in unrestrained subjects, can expose subtle warning signals that are typically masked by traditional measurement methods or anesthesia. This presentation aims to evaluate how refined tools and methodology can offer a more rigorous framework for de-risking molecules early in the development process of new compounds.
About Will : Will completed his studies at Bishop’s University and Sherbrooke University, studying cardiac physiology in the context of various pathologies. Joining the IPS Therapeutique team in 2020, he’s been heavily involved in all studies involving telemetry data. Now lead study director of IPST’s cardiac team, Will coordinates a group focused on the advancement surgical and analytical methodologies, and their implementation in preclinical efficacy and safety studies.
By browsing this website, you accept the use of cookies for statistical purposes.
When you visit any web site, it may store or retrieve information on your browser, mostly in the form of cookies. Control your personal Cookie Services here.
