The same system can be used in either Langendorff or Working Heart Mode. While designed for mice and rat hearts, the system can be adapted for use with rabbits and guinea pigs as well.
Multiple perfusion head designs and bubble trap sizes facilitate this adaptation across species. Various ports for instrumentation and injections are present, including electrical stimulation for pacing.
Users can perfuse up to three physiological liquids. The three easily configurable perfusion mode options controlled through our automated pressure flow regulator include:
Over thirty years of Langendorff experience, EMKA has optimized a user-friendly interface capable of a simple transition between Langendorff and Working Heart Mode.
This fully integrated system includes organized, easily accessible, and clearly labeled tubing. A sliding door opens the heart chamber that has heated walls, and limited dead volume provides optimal temperature regulation.
The ex vivo nature of an isolatedHEART study gives researchers complete environmental control (i.e. temperature, pressure, flow, perfusate, etc.) while removing the normal homeostatic regulation.
This system provides nutrients and oxygen to the organ after its removal from the animal. It allows for the addition of drugs (via the perfusate) and observation of their effect on the organ without the complications involved with in vivo experimentation, such as neuronal and hormonal effects from living animal.
Additionally, the researcher can control many parameters such as perfusate composition, pressure, flow, and oxygenation to create various conditions (i.e. anoxia, hypoxia, hypo/hypertensive). Obtained measurements are highly reproducible and easy to analyze.
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