Skip to content

Solutions
Applications
Services
Knowledge Center
About us

Solutions
Applications
Services
Knowledge Center
About us

Search

Search

Search

Search

Solutions
Applications
Services
Knowledge Center
About us

Solutions
Applications
Services
Knowledge Center
About us

Publications related to Ex vivo studies

emkaBATH tissue baths

emkaBATH tissue baths & myographs

Isolated Heart Perfusion

Isolated heart system

Cardiovascular studies

Doha Marrakchi Ben Jaafar et al. Endothelium-dependent and adrenergic involvement in the biphasic vascular effects of a phenolic-rich ethanolic fraction from male Cannabis sativa inflorescences, Scientific African, Volume 32, 2026
Dylan Le Jan et al. Therapeutic effects of vitamin D and omega-3 supplementation on HFHS diet-induced endothelial dysfunction in Wistar rats, Current Research in Pharmacology and Drug Discovery, 2025
Lars Saemann,et al. Age, sex, and vessel region affect the vasomotor function and gene expression signature of the aorta in mice, Journal of Molecular and Cellular Cardiology Plus, 2025
Chaimae ALLA et al. Hypotensive and potent vasorelaxant effects of the methanolic extract of Ziziphus lotus (L.) Lam: Involvement of NO/SERCA Pathway and Activation of Kir Channels, Scientific African, Volume 29, 2025,
HTK vs. HTK-N for Coronary Endothelial Protection during Hypothermic, Oxygenated Perfusion of Hearts Donated after Circulatory Death. Lars Saemann et al. International Journal of Molecular Sciences. 2024
Bread crust extract protects rats’ vascular grafts from in vitro ischemia/reperfusion injury. Sevil Korkmaz-Icöz et al. Journal of Functional Foods, 2022.
Aqueous extract of large cardamom inhibits vascular damage, oxidative stress, and metabolic changes in fructose-fed hypertensive rats. Kanthal Sk et al. Clin Exp Hypertens, 2021
Mesenchymal stem cell-derived conditioned medium protects vascular grafts of brain-dead rats against in vitro ischemia/reperfusion injury. Sevil Korkmaz-Icoz et al. Stem Cell research and therapy 2021.
Dual effect of nifedipine on pregnant human myometrium contractility: Implication of TRPC1. Lucile Yart et al. J Cell Physiol. 2021
The hypertensive effect of sorafenib is abolished by sildenafil. Dabire et al, Cardio-Oncology. 2020

Respiratory applications

NGF increases Connexin-43 expression and function in pulmonary arterial smooth muscle cells to induce pulmonary artery hyperreactivity. Guillaume Cardouat et al. Biomedicine & Pharmacotherapy, 2024.
New flavonoids with multiple bronchodilator activity pathways from Tephrosia purpurea L. (Pers.) growing in Saudi Arabia. Maged S. Abdel-Kader et al. Saudi Pharmaceutical Journal. 2024
Monensin inhibits mast cell mediated airway contractions in human and guinea pig asthma models. Liu, J., Nie, M., Dong, C. et al. Sci Rep 12, 18924 (2022)
Optimization of Long-Acting Bronchodilator Dose Ratios Using Isolated Guinea Pig Tracheal Rings for Synergistic Combination Therapy in Asthma and COPD. Elena Menchi et al. Pharmaceuticals 2022
In Silico and Ex Vivo Studies on the Spasmolytic Activities of Fenchone Using Isolated Guinea Pig Trachea. Najeeb Ur Rehman et al. Molecules 2022.
Evaluation of Bronchodilatory and antimicrobial activities of Otostegia fruticose: A multi-mechanistic approach. Mohd Nazam Ansari et al, Saudi Pharmaceutical Journal, 2020
Relaxant effect of ghrelin on guinea pig isolated tracheal smooth muscle: role of epithelial NO and PGE2. Mohammed Saeed Zayed Al-Ayed, European Journal of Physiology, 2018
Bronchodilation induced by PGE2 is impaired in group III pulmonary hypertension. Gulsev Ozen et al. British Journal of Pharmacology 2019.
Pharmacological Evaluation of the Bronchorelaxant Effect of Waltheria indica L. (Malvacae) Extract on Rat Trachea. Rainatou Boly et Al, Evidence-Based Complementary and Alternative Medicine, 2021

Neuroscience applications

Martínez-Carranza, M., Škerlová, J., Lee, PG. et al. Activity of botulinum neurotoxin X and its structure when shielded by a non-toxic non-hemagglutinin protein. Commun Chem 7, 179 (2024)
Clozapine Disrupts Endothelial Nitric Oxide Signaling and Antioxidant System for its Cardiovascular Complications. Gayathri M. Nair et al, Drug Research, 2019
Botulinum Neurotoxins Serotypes A and B induce paralysis of mouse striated and smooth muscles with different potencies. Jacquie Maignel-Ludop et al, Pharmacol Res Perspect . 2017
Augmentation of VAMP-catalytic activity of botulinum neurotoxin serotype B does not result in increased potency in physiological systems. Elliott et al, Plos one. 2017
Ibrahim, H.; Retailleau, K.; Hornby, F.; Maignel, J.; Beard, M.; Daly, D.M. A Novel Catalytically Inactive Construct of Botulinum Neurotoxin A (BoNT/A) Directly Inhibits Visceral Sensory Signalling. Toxins 2024, 16, 30.

Calcium Channel Inhibitory Effect of Marjoram (Origanum majorana L.): Its Medicinal Use in Diarrhea and Gut Hyperactivity. Najeeb Ur Rehman et al. Front. Biosci. 2024
Pharmacological Basis for the Antidiarrheal and Antispasmodic Effects of Cuminaldehyde in Experimental Animals: In Silico, Ex Vivo and In Vivo Studies. Mohd Nazam Ansari et al. Front. Biosci. 2024
The detailed pharmacodynamics of the gut relaxant effect and GC-MS analysis of the Grewia tenax fruit extract: In vivo and ex vivo approach. Rehmanet al. Molecules 27(24): 8880. 2022
Dual inhibition of phosphodiesterase and Ca++ channels explain the medicinal use of Balanites aegyptiaca (L.) in hyperactive gut disorders. Plants-Basel 11(9):1183. Rehman, et al. 2022.
GC-MS analysis, in vivo and ex vivo antidiarrheal and antispasmodic effects of the methanolic extract of Acacia nilotica. Molecules 27(7), Rehman et al, 2022.

Olejnik, A., Krzywonos-Zawadzka, A., Sambor, I. et al. Klotho protein alleviates heart ischemia/reperfusion injury and oxidative stress through regulation of the NOS/MMP pathway. Sci Rep 15, 32299 (2025).
Anti-rheumatic property and physiological safety of KMU-11342 in in vitro and in vivo models. Hye Suk Baek et al. Inflammation Reasearch, 2024.
Selective blockade of Cav1.2 (α1C) versus Cav1.3 (α1D) L-type calcium channels by the black mamba toxin calciseptine. Pietro Mesirca et al. Nature communication. 2024
Klotho inhibits IGF1R/PI3K/AKT signalling pathway and protects the heart from oxidative stress during ischemia/reperfusion injury. Olejnik, A., Radajewska, A., Krzywonos-Zawadzka, A. et al.Sci Rep 13, 20312 (2023).
Cell-autonomous and non-cell-autonomous effects of arginase-II on cardiac aging. Duilio M. Potenza et al. BioRxiv. 2023
KMU-191 Induces Apoptosis in Human Clear Cell Renal Cell Carcinoma Caki Cells Through Modulation of Bcl-xL, Mcl-1 (L), c-FLIP (L), and p53 Proteins. Shin Kim et al. J Cancer. 2023 Jul 16.
Characterization of sinoatrial automaticity in Microcebus murinus to study the efect of aging on cardiac activity and the correlation with longevity. Mattia L. DiFrancesco et al. Sci Rep 13, 3054 (2023)
Silencing RNA for MMPs May Be Utilized for Cardioprotection. Marta Banaszkiewicz et al. Hindawi Cardiovascular Therapeutics. 2022
Arrhythmogenic Hearts in PKD2 Mutant Mice Are Characterized by Cardiac Fibrosis, Systolic, and Diastolic Dysfunctions. Farideh Amirrad et al. Frontiers in Cardiovascular Medicine, 2021
Ameliorating Effect of Klotho Protein on Rat Heart during I/R Injury. Agnieszka Olejnik et al. Oxidative Medicine and Cellular Longevity, Volume 2020
Ciliotherapy: Remote Control of Primary Cilia Movement and Function by Magnetic Nanoparticles. Rajasekharreddy Pala et al, ACS Nano (2019)
Klotho protein contributes to cardioprotection during ischaemia/reperfusion injury. Agnieszka Olejnik et al. J Cell Mol Med. 2020
MK2-deficient mice are bradycardic and display delayed hypertrophic remodelling in response to a chronic increase in afterload. Matthieu Ruiz et al. bioRxiv. 2020
A drug cocktail for protecting against ischemia-reperfusion injury. Anna Krzywonos-Zawadzka et al. Frontiers in Bioscience, 2020
Study of Intrinsic Cardiac Dysfunction in Septic Shock Conditions by Isolated Working Heart: A Primary Approach before New Therapeutic Proposals? Marine Ferron et al. SM Emerg Med Crit Care. 2017

Products

In vivo
Ex vivo
Software
See all

Applications

Cardiovascular
Respiratory
Neuroscience
See all

Services

Installation & training
Technical Support
Maintenance
Surgery

Knowledge Center

Researcher spotlights
Publications
Blog
Resources

Company

About Us
Contact Us
Events
Legal notices

←
Linkedin