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Publications related to noninvasive systems

emkaPACK system for large animals

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Voronkov M, Nikonov G, Uzbil M, Milevich G, Abernethy J, Barthélémy I. Is Fentanyl Rebound an Intrinsic Feature of Naloxone Reversal? Pharmaceuticals. 2025
Zhang X, Yuan B, Li C, Wang H, Wei S, Tian J, Duan S. Preclinical Evaluation of the Oral Toxicity, Genotoxicity, and Safety Pharmacology of LPM4870108, a Novel Potent Tropomyosin Receptor Kinase Inhibitor. Pharmacol Res Perspect. 2025 Aug
Van Nhut Khanh Dong, Anusak Kijtawornrat. Safety profile of SGLT-2 inhibitors on cardiac autonomic nervous system inferred from heart rate variability in healthy beagle dogs instrumented with jacket telemetry, Journal of Pharmacological and Toxicological Methods, Volume 133, 2025
Charlene Pius et al. A refined, minimally invasive, reproducible ovine ischaemia–reperfusion–infarction model using implantable defibrillators: Methodology and validation. Experimental Physiology. 2024
Barthélémy, I., Su, J.B., Cauchois, X. et al. Ambulatory electrocardiographic longitudinal monitoring in a canine model for Duchenne muscular dystrophy identifies decreased very low frequency power as a hallmark of impaired heart rate variability. Sci Rep (2024).
Olgotrelvir, a dual inhibitor of SARS-CoV-2 Mpro and cathepsin L, as a standalone antiviral oral intervention candidate for COVID-19. Long Mao et al. Med, 2024.
Cardoso, D., Barthélémy, I., Blot, S. et al. Replenishing NAD+ content reduces aspects of striated muscle disease in a dog model of Duchenne muscular dystrophy. Skeletal Muscle 13, 20 (2023)
An IgM-like inhalable ACE2 fusion protein broadly neutralizes SARS-CoV-2 variants. Liu, J., Mao, F., Chen, J. et al. Nature Communication. 2023
The toxicity assessment of neorudin in cynomolgus monkeys. Yu-bin Liu et al. The Journal of Toxicological Sciences (J. Toxicol.) 2023
A novel minimally invasive and reproducible large animal ischaemia-reperfusion-infarction model: methodology and model validation. Charlene Pius et al. bioRxiv. 2023
Preclinical Toxicity and Immunogenicity of a COVID-19 Vaccine (ZF2001) in Cynomolgus Monkeys. Hongzhong Yang et al. Vaccines 2022
Feasibility Studies of Nebulized SARS-CoV-2 Neutralizing Antibody in Mice and Cynomolgus Monkeys. Jilei Jia et al. Pharmaceutical Research. 2022
Hesham Farag (2022). Circadian Medicine: Pioneering Translational Applications from Human to Veterinary Clinical Care. [Master of Science in Biomedical Sciences dissertation, The University of Guelph]
Supplemental Fiber Affects Body Temperature and Fecal Metabolites but Not Respiratory Rate or Body Composition in Mid-Distance Training Sled Dogs. Emma Thornton et al. Front. Vet. Sci., 29 April 2021
Intranasal epinephrine in dogs: Pharmacokinetic and heart rate effects. Kenneth L. Dretchen et al, Pharmacol Res Perspect. 2020
Acute and Subchronic Toxicities and Safety Pharmacology Studies of a Bacillus Subtilisin in Dogs. Shuai Xiao et al. Biol. Pharm. Bull.44, 211–218 (2021)
Toxicological testing of allogeneic secretome derived from peripheral mononuclear cells (APOSEC): a novel cell-free therapeutic agent in skin disease. Silvio Wuschko et al, Scientific reports, 2019
Genetic Toxicology and Safety Pharmacological Evaluation of Forsythin, Han et al. Evidence-Based Complementary and Alternative Medicine. 2021
Development of a methodology to measure the effect of ergot alkaloids on forestomach motility using real-time wireless telemetry. Amanda Marie Egert et al, Frontiers in chemistry (2014)
Exercise but Not Supplemental Dietary Tryptophan Influences Heart Rate and Respiratory Rate in Sled Dogs, Thornton et al, Veterinary Sciences. 2020
Evaluation of oscillometric and vascular access port arterial blood pressure measurement techniques versus implanted telemetry in anesthetized cats. Raphael J Zwijnenberg et al, Am J Vet Res (2011)
Cardiorespiratory safety evaluation in non-human primates. Jennifer L Ingram-Ross et al, J Pharmacol Toxicol Methods (2012)

Euler G, Heger J, Rossol M, Schulz R, Parahuleva M, Kockskämper J. Maintenance and Reversibility of Paroxysmal Atrial Fibrillation in JDP2 Overexpressing Mice. Cells. 2025 Jul 15.
Vandeputte, M., et al. Elucidating the harm potential of brorphine analogues as new synthetic opioids: Synthesis, in vitro, and in vivo characterization. (2024). Neuropharmacology, 260 110113
On the Mechanisms of the Cardiotoxic Effect of Lead Oxide Nanoparticles. Minigaliyeva, I.A., Klinova, S.V., Sutunkova, M.P. et al. Cardiovasc Toxicol (2023)
Evidence of sex differences in cancer‐related cardiac complications in mouse models of pancreatic and liver cancer. Anna Gams et al. Physiol Rep. 2023
The Old and the New: Cardiovascular and Respiratory Alterations Induced by Acute JWH-018 Administration Compared to Δ9 -THC—A Preclinical Study in Mice. Beatrice Marchetti et al. International Journal of Molecular Sciences. 2023
Demographic and Methodological Heterogeneity in Electrocardiogram Signals From Guinea Pigs. Kazi T. Haq et al. Frontier in Physiology. 2022
Actin-microtubule cytoskeletal interplay mediated by MRTF-A/SRF signaling promotes dilated cardiomyopathy caused by LMNA mutations. Caroline Le Dour et al. Nature Communications. 2022
Heart Rate Variability Reveals Altered Autonomic Regulation in Response to Myocardial Infarction in Experimental Animals. Emanuele Pizzo et al. Front. Cardiovasc. Med., 2022
Electrocardiographic changes are strongly correlated with the extent of cardiac inflammation in mice with Coxsackievirus B3-induced viral myocarditis. Linghe Wu et al. Cardiovascular Pathology. 2021
Effects of mango and mint pod-based e-cigarette aerosol inhalation on inflammatory states of the brain, lung, heart, and colon in mice. Alex Moshensky et al. eLife. 2022
Differential cardiotoxic electrocardiographic response to doxorubicin treatment in conscious versus anesthetized mice. Warhol, Anna., et al. Physiol Rep. 2021
Genetic Ablation of G Protein-Gated Inwardly Rectifying K+ Channels Prevents Training-Induced Sinus Bradycardia. Isabelle Bidaud et al. Front. Physiol., 20 January 2021
Chronic Perinatal Hypoxia Delays Cardiac Maturation in a Mouse Model for Cyanotic Congenital Heart Disease. Jennifer Romanowicz et al, Am J Physiol Heart Circ Physiol, 2021
Rhythm dynamics of the aging heart: an experimental study using conscious, restrained mice. Martina Comelli et al, American Journal of Physiology, 2020
Hypochlorhydria reduces mortality in heart failure caused by Kcne2 gene deletion. Ulrike Lisewski et al, The Faseb journal, 2020
Combined Treatment with Peptide-Conjugated Phosphorodiamidate Morpholino Oligomer-PPMO and AAV-U7 Rescues the Severe DMD Phenotype in Mice. Anne Forand et al, Molecular Therapy Method & Clinical Development, 2020
Structural, Pro-Inflammatory and Calcium Handling Remodeling Underlies Spontaneous Onset of Paroxysmal Atrial Fibrillation inJDP2-Overexpressing Mice. Mariana S. Parahuleva et al, Int. J. Mol. Sci. 2020.
Manifestation of Systemic Toxicity in Rats after aShort-Time Inhalation of Lead Oxide Nanoparticles. Marina P. Sutunkova et al, International Journal of Molecular Sciences, 2020
Microtubule cytoskeleton regulates connexin 43 localization and cardiac conduction in cardiomyopathy caused by mutation in A-type lamins gene. Coline Macquart et al, 2018

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