Phenotyping Arrhythmia & Arrhythmogenicity in Preclinical Models

Case Studies in Pharmacology and Toxicology

In our recent SOT 2023 hosted session, we discussed the electrocardiographic traits of arrhythmias in rodents and large animals with Dr. Alex Carll (University of Louiseville, KY) and Dr. Kenta Nakamura (University of Washington, WA).

They presented their research interests and discussed:

  • The Art of Phenotyping Cardiac Arrhythmias in Rodents
  • Mitigating transient arrhythmogenicity in pig following human cardiomyocyte transplantation through electrophysiologic and genetic phenotyping


This document summarizes some of the key points that were presented. A link to the full panel discussion recording is available in this document.

Learn more about our speakers

DR. ALEX CARLL –  University of Louisville, KY, USA

Dr. Alex Carll is an Assistant Professor in the Department of Physiology and Center for Cardiometabolic Science at the University of Louisville, KY, USA. 

He studies the mechanisms by which inhaled toxins impair cardiac conduction and contraction, in both rodents and humans, with particular interest in the autonomic nervous system’s role. He studies the impacts of multiple inhaled agents, including e-cigarette aerosols, volatile organic compounds, and particulate matter from many sources (cars, urban atmospheres, and consumer products).

DR. KENTA NAKAMURA M.D., F.A.C.C. at University of Washington, WA, USA

Dr. Nakamura is Director of Preclinical Research at the UW Medicine Heart Regeneration Program. This translational research focuses on pluripotent stem cell-based cardiac remuscularization therapies using various preclinical models to optimize the efficacy, safety, engraftment and maturation of cardiomyocyte transplantation through novel genetic, metabolic, immunomodulatory, antiarrhythmic and delivery strategies.

Dr. Nakamura obtained his medical degree at the University of California, San Francisco and clinical training at the Massachusetts General Hospital/Harvard Medical School with post-doctoral studies at the Massachusetts Institute of Technology. He is an Assistant Professor of Medicine at the University of Washington and directs the Cardiac Catheterization Laboratory at the VA Puget Sound Healthcare System.

Download the summary

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