Optogenetics is a revolutionary biological technique that uses light to control and study neural pathways by activating light-sensitive proteins. This powerful method is widely applied in neuroscience to control real-time neuronal activity and investigate brain functions. Optogenetics holds significant promise in developing therapies for neurological disorders such as Parkinson’s disease, epilepsy, and depression, by offering precise control over neural circuits.
Ideal for preclinical optogenetics studies, this system allows continuous, non-invasive monitoring of physiological parameters in rodents or large animals. Track heart rate, body temperature, and blood pressure during optogenetic experiments to correlate physiological changes with neuronal activity.
Digital telemetry can be combined with whole body plethysmography for neurological and cardiorespiratory measurements.
Implantable telemetry is especially valuable for long-term studies, as it eliminates the need for repeated handling. By combining telemetry with optogenetics, researchers can correlate physiological changes with behavioral outcomes, improving the reliability and consistency of the data.
easyTEL+ implantable telemetry can acquire multiple biopotentials (ECG, EEG, EMG), blood pressure, core temperature and activity in small and large animals for up to 330 days.
Transmitter state (on/sleep) and reconfigurable settings (sampling rate, resolution, transmission power, transmission frequency, etc.) can be controlled wirelessly, reducing human interactions.
The easyTEL+RP system utilizes reusable external telemeters, which can be shared across different subjects, cohorts, and research studies, significantly lowering initial costs for behavioral research that requires a large number of subjects. Our transmitters are custom-designed with adjustable electrodes, electrode wires, and polarity, along with configurable options for sampling rate, resolution, and gain, allowing for flexible study setups. The easily replaceable batteries offer up to 150 hours of continuous recording.
For rodent subjects (weighing from 200g), the easyTEL+RP captures up to four low-noise biopotentials, including cortical or penetrating EEG, EMG, ECG, and EOG, as well as activity data.
In large animal studies, the system monitors neurological and activity changes without the need for surgical implantation. Instead, the telemeter is housed in an external jacket or helmet, with surface leads placed on the scalp to collect data.
The neural control of breathing involves an integrated orchestration between several dedicated brain stem circuits, along with higher brain areas such as cortex, limbic system and hypothalamus. This higher brain function interprets peripheral feedback and innervates the muscles and lungs to regulate breathing rates and rhythms.
Optogenetics studies targeting respiratory centers in the brain stem can be paired with Whole body plethysmography (WBP) to measure pulmonary function as result of optical manipulation of the nervous system. WBP permits a continuous assessment of breathing patterns in freely moving, conscious subjects and provides important parameters such as breathing frequency and duration, estimates of tidal volume and minute ventilation. IOX2 software allows for customized protocols and analysis on a breath by breath basis to capture respiratory changes in real-time.
The WBP chamber can be combined with a removable swivel tower, attached to the top of the chamber which allows for the subject to have full range of motion while keeping the integrity of the tethered fiber optic cable.
Whole body plethysmography and digital telemetry can be combined on a synchronized platform, for concurrent analysis of respiratory, cardiovascular and neurological data.
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