Rats for cardiovascular research
Because of the multifactorial nature of cardiovascular diseases, there is not a single specie which is optimal for all studies. The choice of an animal model should be carefully made as it can affect the experimental outcomes and the reasonable translation of study findings to humans.
Cancer and Chemotherapy-induced Cardiotoxicity
To develop safe and effective cancer therapies, it is crucial to understand chemotherapy-induced cardiotoxicity and cancer‐related cardiac complications. This blog highlights recent discoveries in this field.
Cell-based & cell-free therapies for myocardial infarction
After myocardial infarction, the heart fails to regenerate and ischemic/reperfusion injury leads to cardiomyocyte loss and fibrosis leading to impaired heart function. The medical treatment for heart failure, for the most part, is not disease modifying, it’s simply symptomatic. Another strategy is to address the fundamental issue of a failing heart, which is the loss of cardiomyocytes after a heart attack.
Maximizing Insights from Preclinical Safety Studies in the context of rising costs and shortages
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, scientists from leading preclinical contract organizations (CROs) discussed how traditional IND-enabling studies involving primates and dogs can be complemented (and sometimes even replaced) by alternative models such as mice, rats, rabbits and pigs.
Using super-intervals to enhance statistical sensitivity of cardiovascular parameters detection
The use of “super-intervals” improves statistical sensitivity to detect QTc interval prolongation and thus allows to get more robust QTc datasets with reduced signal variability.
The Power of Combining Telemetry and Plethysmography: Powerful Insight Into the Control of Breathing
Combining implantable telemetry with whole body plethysmography offers a powerful approach that provides researchers with an in-depth understanding of respiratory patterns and mechanisms.
The Role of Chx10 Neurons in Global Motor Arrest
In the intricate web of neural circuits that guide our every move, a recent study has shed light on a fascinating phenomenon: the arrest of ongoing movements.
e-cigarettes induce cardiac arrhythmia and conduction defects in mice
In recent years, electronic cigarettes have become rapidly popular worldwide, despite growing evidence that they adversely impact cardiopulmonary health.
Further scientific evidence is needed to clarify the risks of e-cigarettes and guide the use and regulation of these nicotine aerosol delivery devices.
New Mouse Handling Recommendations for Improving Animal and Handler Well-being
All research model systems have unique strengths and challenges regarding the generalizability of data to other systems. Pre-clinical researchers attempt to describe and interact with human clinical phenotypes using animal models.
Implanted telemetry in preclinical research
Implanted telemetry is established as the gold standard for preclinical Drug Development, Safety Pharmacology and Toxicology studies. Let’s understand how it evolved in the last decade and what are the current challenges faced by scientists.
