Refining the Study of Myocardial Infarction in Sheep
This article presents a refined, minimally invasive ovine model of ischaemia–reperfusion–infarction which incorporates implantable defibrillators and addresses many limitations seen in previous approaches, enhancing the safety, reproducibility, and clinical relevance of preclinical cardiac research.
The challenge of cardiovascular toxicity evaluation
The evaluation of cardiovascular toxicity is a significant challenge in drug development. Preclinical evaluation of cardiovascular safety involves a multifaceted approach, encompassing a plethora of in vitro and in vivo endpoints.
Understanding Anorexia Through the Study of Ground Squirrels During Hibernation
For ground squirrels, anorexia is not a pathological condition but an adaptive strategy for survival during hibernation. Recent research by Sarah M. Mohr et al highlights the unique hibernation patterns of thirteen-lined ground squirrels, which could provide valuable insights into anorexia in humans.
The Role of Orexin Neurons in Altered Respiratory Responses and SUDEP Risk
Sudden Unexpected Death in Epilepsy (SUDEP) remains a critical concern in epilepsy management, with the underlying mechanisms still not fully understood.
Measuring body temperature and respiration in running sled dogs
The University of Guelph researchers studied how a diet high in soluble fibers affected sled dogs’ physiological parameters.
To track respiratory rate and body temperature while the dogs were running, they used the emkaPACK jacketed telemetry system.
Assessing the safety of warfare nerve agents antidotes using dual-chamber plethysmography
Despites international treaties, the usage of chemical weapons is still a concern nowadays. This article highlights a study using Dual-chamber plethysmography for the determination of the NOAEL dose of an oxime, for the treatment of organophosphorus-nerve agents poisoning.
Evaluating large Animal models of Heart Failure with hFpEF using clinical scores
Learn about Heart Failure with Preserved Ejection Fraction and the development of large animal models for studying and testing therapies for this complex condition.
Rats for cardiovascular research
Because of the multifactorial nature of cardiovascular diseases, there is not a single specie which is optimal for all studies. The choice of an animal model should be carefully made as it can affect the experimental outcomes and the reasonable translation of study findings to humans.
Cancer and Chemotherapy-induced Cardiotoxicity
To develop safe and effective cancer therapies, it is crucial to understand chemotherapy-induced cardiotoxicity and cancer‐related cardiac complications. This blog highlights recent discoveries in this field.
Cell-based & cell-free therapies for myocardial infarction
After myocardial infarction, the heart fails to regenerate and ischemic/reperfusion injury leads to cardiomyocyte loss and fibrosis leading to impaired heart function. The medical treatment for heart failure, for the most part, is not disease modifying, it’s simply symptomatic. Another strategy is to address the fundamental issue of a failing heart, which is the loss of cardiomyocytes after a heart attack.
