Maximizing Insights from Preclinical Safety Studies in the context of rising costs and shortages
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, scientists from leading preclinical contract organizations (CROs) discussed how traditional IND-enabling studies involving primates and dogs can be complemented (and sometimes even replaced) by alternative models such as mice, rats, rabbits and pigs.
Gastrointestinal motility
The evaluation of the gastrointestinal (GI) motility is useful to detect pathological conditions of the GI system, the therapeutic potential of drugs in motility disorders or potential drug side effects on motility or inflammation.
Integrating SEND outcomes
As an industry partner with deep expertise in IND-enabling studies, emka TECHNOLOGIES helps nonclinical scientists comply with SEND requirements by generating SEND 3.1 compatible tables directly from emka TECHNOLOGIES software.
Studying cardiac dysfunction in septic shock in rat’s isolated perfused heart
Septic shock is a systemic inflammatory response to an infection leading to both cardiovascular dysfunction and cellular metabolic alterations.
In 2017, Marine Ferron et al investigated cardiac changes associated with sepsis, specifically intrinsic contractility and myocardial responses.
