Implanted Rodent Telemetry
During our 2025 SOT seminar, William Salvail (IPS Therapeutique Inc) discussed the benefits of implanted digital telemetry to improve the clinical relevance of non-clinical efficacy and toxicity testing, while Dr. Monica Metea (Preclinical Electrophysiology Consulting, LLC) presented advanced methods for streamlining telemetry electrophysiology analytics.
Metabolic Syndrome
Metabolic Syndrome Metabolic syndrome refers to a cluster of conditions—obesity, insulin resistance, dyslipidemia, and hypertension—that increase the risk of cardiovascular diseases, diabetes, and other health complications such as respiratory diseases. Animal models are commonly used to study the components of metabolic syndrome. Diet-induced models, such as high-fat and high-sucrose diets, are employed to replicate human […]
Baroreflex Sensitivity impairment
Baroreflex Sensitivity impairment The baroreflex is a vital homeostatic mechanism that maintains blood pressure at a steady level, playing a key role in the short-term control of blood pressure. Baroreceptors are located in major arteries and veins, and in the heart. Through their feedback mechanism, they enable the autonomic nervous system to swiftly adjust the […]
COVID-19 studies with emkaPACK
This application note reviews the significant contributions of emkaPACK in the research and development of Olgotrelvir, the ZF2001 vaccine, and nebulized SARS-CoV-2 neutralizing antibodies.
Investigating Arrhythmias using ecgAUTO software
In this application note, we explore a few studies conducted in 2024 and using ecgAUTO software for automated ECG data analysis, aiming to enhance our understanding of arrhythmias and develop targeted interventions.
Cardiomyopathy
Cardiomyopathy Cardiomyopathy is a group of diseases that affect the myocardium. The heart muscle becomes enlarged, thickened, or stiff, which can lead to problems with the heart’s ability to pump blood effectively, and can cause heart failure, cardiac fibrosis or arrhythmias. This condition can be caused by a variety of factors, including genetics (syndrome of […]
Use of the rat in cardiovascular screening assays
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, Dr. Michael Stonerook (AmplifyBio, OH, USA) highlighted the benefits and limitations of the rat model for cardiovascular screening assays.
Accurately Phenotyping Arrhythmia in rodents
Finding arrhythmias in rodents can be tedious, thrilling, and controversial. During the 2023 Society of Toxicology (SOT) conference in Nashville, Dr. Alex Carll discussed rodent ECG morphology and physiologic vs. pathologic arrhythmias in mice and rats.
Mitigating transient arrhythmogenicity in pig following human cardiomyocyte transplantation
To achieve therapeutic cardiac regeneration, the University of Washington Medicine Heart Regeneration Program has been focusing on remuscularization with genuine cardiomyocytes derived from pluripotent stem-cells.
Autonomic dysfunction
Autonomic dysfunction The Autonomic Nervous System, comprising the Sympathetic Nervous System (SNS) and Parasympathetic Nervous System (PNS), regulates essential physiological functions such as heart rate and blood pressure. These systems help control blood pressure through the baroreflex (or baroreceptor reflex) mechanism(1). The baroreflex is a homeostatic physiological mechanism that regulates blood pressure at constant levels. […]
