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Cardiomyopathy

Cardiomyopathy Cardiomyopathy is a group of diseases that affect the myocardium. The heart muscle becomes enlarged, thickened, or stiff, which can lead to problems with the heart’s ability to pump blood effectively, and can cause heart failure, cardiac fibrosis or arrhythmias. This condition can be caused by a variety of factors, including genetics (syndrome of […]

Use of the rat in cardiovascular screening assays

Use of the rat in cardiovascular screening

Use of the rat in cardiovascular screening assays During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, scientists from leading preclinical contract organizations (CROs) discussed how traditional IND-enabling studies involving primates and dogs can be complemented (and sometimes even replaced) by alternative models such as mice, rats, rabbits and pigs. Dr. Michael Stonerook (AmplifyBio, […]

Accurately Phenotyping Arrhythmia in rodents

Phenotyping Arrhythmia in rodents

Accurately Phenotyping Arrhythmia in rodents Finding arrhythmias in rodents can be tedious, thrilling, and controversial. During the 2023 Society of Toxicology (SOT) conference in Nashville, Dr. Alex Carll discussed rodent ECG morphology and physiologic vs. pathologic arrhythmias in mice and rats. This article summarizes some of the key points that were presented during the event […]

Mitigating transient arrhythmogenicity in pig following human cardiomyocyte transplantation

Mitigating transient arrhythmogenicity in pig

Mitigating transient arrhythmogenicity in pig following human cardiomyocyte transplantation To achieve therapeutic cardiac regeneration, the University of Washington Medicine Heart Regeneration Program has been focusing on remuscularization with genuine cardiomyocytes derived from pluripotent stem-cells. Dr. Nakamura presented his work during the 2023 Society of Toxicology (SOT) conference in Nashville. This article summarizes some of the […]

Autonomic dysfunction

Autonomic dysfunction

Autonomic dysfunction The Autonomic (involuntary) Nervous System incorporates two branches which are the Sympathetic Nervous System (SNS) and Parasympathetic Nervous System (PNS). These branches innervate all body organs, including the cardiovascular system. The SNS and PNS help to control blood pressure and heart rate through baroreflexes/baroreceptor reflex control(1) and is understood to be responsible for […]

Vascular function study using a myograph

emkaMYO2 myograph

Vascular reactivity study using a myograph Myographs are used to determine the myogenic tone, evaluate the impact of treatment on Vascular Smooth Muscle Cells contractility and study endothelial function. This application note includes: An introduction about wire myography The list of material required for small and large vessel dissection Dissection and isolation tips Tissue mounting […]

Preclinical Blood Pressure Measurements

Preclinical Blood Pressure measurements In our recent SPS 2022 hosted session, we discussed the Translational Assessment of Pressor Effects of Drugs with Dr.Christine Garnett (FDA), Dr.Todd Wisialowski (Pfizer) and Dr.Brian Roche (Charles River). They presented a short overview of their work before participating in the discussion and sharing their expertise on pressure liabilities in drug […]

E-cigarettes induce Cardiac Arrhythmia and Conduction Defects In Mice

e-cigarettes induce cardiac arrhythmia and conduction defects in mice This document provides a summary of the study by Dr. Carll et al. at the University of Louisville published in Nature Communications: E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice. Carl, A., et al. (2022). Nature Communications, 13(1):6088. doi: 10.1038/s41467-022-33203-1. It […]

Understanding Pattern Recognition

ecgAUTO software waterfall

Understanding Pattern Recognition This document provides an overview of ecgAUTO’s analysis methodologies and capabilities for preclinical cardiovascular research, including ECG Interval and Arrhythmia analysis. It includes: ECG interpretation and physiological description ecgAUTO standard workflow Applications of automated ECG analysis (Abnormal event detection, variability analysis, visualization of large dataset)

Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment

Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment

Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment: The Need to Read Between the Line This presentation given by Simon Authier, DVM, MBA, PhD, DSP Deputy Chief Scientific Officer at CitoxLab North America in 2019, compares well established ECG analysis methods used in toxicology with novel strategies that may offer lower false positive rates. The ECG’s […]

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