Baroreflex Sensitivity impairment
Baroreflex Sensitivity impairment The baroreflex is a vital homeostatic mechanism that maintains blood pressure at a steady level, playing a key role in the short-term control of blood pressure. Baroreceptors are located in major arteries and veins, and in the heart. Through their feedback mechanism, they enable the autonomic nervous system to swiftly adjust the […]
COVID-19 studies with emkaPACK
This application note reviews the significant contributions of emkaPACK in the research and development of Olgotrelvir, the ZF2001 vaccine, and nebulized SARS-CoV-2 neutralizing antibodies.
Investigating Arrhythmias using ecgAUTO software
In this application note, we explore a few studies conducted in 2024 and using ecgAUTO software for automated ECG data analysis, aiming to enhance our understanding of arrhythmias and develop targeted interventions.
Cardiomyopathy
Cardiomyopathy Cardiomyopathy is a group of diseases that affect the myocardium. The heart muscle becomes enlarged, thickened, or stiff, which can lead to problems with the heart’s ability to pump blood effectively, and can cause heart failure, cardiac fibrosis or arrhythmias. This condition can be caused by a variety of factors, including genetics (syndrome of […]
Use of the rat in cardiovascular screening assays
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, Dr. Michael Stonerook (AmplifyBio, OH, USA) highlighted the benefits and limitations of the rat model for cardiovascular screening assays.
Accurately Phenotyping Arrhythmia in rodents
Finding arrhythmias in rodents can be tedious, thrilling, and controversial. During the 2023 Society of Toxicology (SOT) conference in Nashville, Dr. Alex Carll discussed rodent ECG morphology and physiologic vs. pathologic arrhythmias in mice and rats.
Mitigating transient arrhythmogenicity in pig following human cardiomyocyte transplantation
To achieve therapeutic cardiac regeneration, the University of Washington Medicine Heart Regeneration Program has been focusing on remuscularization with genuine cardiomyocytes derived from pluripotent stem-cells.
Autonomic dysfunction
Autonomic dysfunction The Autonomic (involuntary) Nervous System incorporates two branches which are the Sympathetic Nervous System (SNS) and Parasympathetic Nervous System (PNS). These branches innervate all body organs, including the cardiovascular system. The SNS and PNS help to control blood pressure and heart rate through baroreflexes/baroreceptor reflex control(1) and is understood to be responsible for […]
Vascular function study using a myograph
Myographs are used to determine the myogenic tone, evaluate the impact of treatment on Vascular Smooth Muscle Cells contractility and study endothelial function.
Preclinical Blood Pressure Measurements
In our SPS 2022 hosted session, we discussed the Translational Assessment of Pressor Effects of Drugs with Dr.Christine Garnett (FDA), Dr.Todd Wisialowski (Pfizer) and Dr.Brian Roche (Charles River).
