Cardiomyopathy
Cardiomyopathy Cardiomyopathy is a group of diseases that affect the myocardium. The heart muscle becomes enlarged, thickened, or stiff, which can lead to problems with the heart’s ability to pump blood effectively, and can cause heart failure, cardiac fibrosis or arrhythmias. This condition can be caused by a variety of factors, including genetics (syndrome of […]
Use of the rat in cardiovascular screening assays
During the 2023 Safety Pharmacology Society (SPS) Conference in Brussels, Dr. Michael Stonerook (AmplifyBio, OH, USA) highlighted the benefits and limitations of the rat model for cardiovascular screening assays.
Accurately Phenotyping Arrhythmia in rodents
Finding arrhythmias in rodents can be tedious, thrilling, and controversial. During the 2023 Society of Toxicology (SOT) conference in Nashville, Dr. Alex Carll discussed rodent ECG morphology and physiologic vs. pathologic arrhythmias in mice and rats.
Mitigating transient arrhythmogenicity in pig following human cardiomyocyte transplantation
To achieve therapeutic cardiac regeneration, the University of Washington Medicine Heart Regeneration Program has been focusing on remuscularization with genuine cardiomyocytes derived from pluripotent stem-cells.
Autonomic dysfunction
Autonomic dysfunction The Autonomic (involuntary) Nervous System incorporates two branches which are the Sympathetic Nervous System (SNS) and Parasympathetic Nervous System (PNS). These branches innervate all body organs, including the cardiovascular system. The SNS and PNS help to control blood pressure and heart rate through baroreflexes/baroreceptor reflex control(1) and is understood to be responsible for […]
Vascular function study using a myograph
Myographs are used to determine the myogenic tone, evaluate the impact of treatment on Vascular Smooth Muscle Cells contractility and study endothelial function.
Preclinical Blood Pressure Measurements
In our SPS 2022 hosted session, we discussed the Translational Assessment of Pressor Effects of Drugs with Dr.Christine Garnett (FDA), Dr.Todd Wisialowski (Pfizer) and Dr.Brian Roche (Charles River).
E-cigarettes induce Cardiac Arrhythmia and Conduction Defects In Mice
This document provides a summary of the study by Dr. Carll et al. at the University of Louisville published in Nature Communications.
Understanding Pattern Recognition
This document provides an overview of ecgAUTO’s analysis methodologies and capabilities for preclinical cardiovascular research, including ECG Interval and Arrhythmia analysis.
Recent Advances in ECG Analysis for ProArrhythmia Risk Assessment
This presentation given by Simon Authier, DVM, MBA, PhD, DSP Deputy Chief Scientific Officer at CitoxLab North America in 2019, compares well established ECG analysis methods used in toxicology with novel strategies that may offer lower false positive rates.
