The presentation will discuss the evaluation of emka’s non-invasive impedance system for respiratory assessment, using emkaPACK Jacketed Telemetry System.
Through standard external ECG leads both ECG and external respiratory impedance data will be compared against the proven RIP system using positive control agents. Additionally, calibration stability will be evaluated over time through pre and post calibration checks.
Finally, the presentation will demonstrate methods of recovering data in the event of inaccurate pneumotach calibrations using scaling utilities within ecgAUTO.
During this session, speakers will examine critical factors for robust and reliable in vitro and in vivo aerosol exposure studies with inhaled therapeutics and with airborne toxicants such as e-cigarettes.
The speakers will discuss the importance of establishing correlations between in vitro and in vivo outcomes, and explore the respective strengths and limitations of mouse and airway-liquid interface (ALI) models.
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Join us at booth #816-818 to get a demonstration of our solutions for preclinical toxicology studies.
Snapshot-ECG recordings are the mainstay of cardiovascular toxicity studies owing to their cost-effectiveness and vast amount of reference data. The emkaPACK5 can be configured in a mobile snapshot ECG recording system, where the receiver and PC are wheeled into the subject room for maximum efficiency and flexibility. The mobile system is used in combination with the emkaPACK5 transmitter to obtain snapshot ECG measurements.
In a jacketed telemetry study, large animals (canine, primate, swine, sheep, other) are equipped with custom-designed clothing and instrumented with the emkaPACK5 transmitter, which wirelessly transmits physiological signals from the ambulatory subjects.
Jacketed telemetry is often considered more sensitive and reproducible than traditional “snapshot” recordings in restrained animals.
An easyTEL+ M2 implant can be added for the acquisition of minimally invasive blood pressure and core temperature. Uniquely adapted to toxicology studies, this implant equipped with a 2F or 4.5F pressure catheter, is intended for subcutaneous placement in small primates or other large animal models.
Implanted telemetry remains the gold standard for toxicology studies in terms of signal quality and data coverage.
emka’s M series is uniquely adapted to toxicology studies. The implant is small and light, with 2F or 4.5F pressure catheters. It is intended for subcutaneous placement in small primates or other large animal models for the acquisition of minimally invasive blood pressure, ECG, temperature, and activity signals. ECG leads come with solid tip for intravascular ECG.
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