Techniques & Measurements

This page describes the technique and measurements employed by
the easyTEL system for mice to measure cardiovascular and neurological outcomes.

Implanted telemetry

Physiological measurements are captured and amplified by a transmitter surgically implanted and wirelessly transmitted to a receiver, placed under the cage.

The easyMATRIX3 device, placed between the receiver and the computer, digitizes and encodes the signals that are sent to the acquisition computer running IOX2 software.

Outcomes

Electrocardiogram (ECG), electroencephalogram (EEG), electromyogram (EMG) or electrooculogram (EOG) signals can be retrieved using easyTEL system through implanted electrodes.

Single lead Biopotential: using a 2-wire electrode, to get 1-lead ECG, or 1 EEG, EOG or EMG. For ECG, Lead II placement is usually chosen (but not necessarily).
Core Body Temperature
Activity, detected by the receiver, from the signal intensity variation

Reference

Pedunculopontine Chx10⁺ neurons control global motor arrest in mice. Goñi-Erro, H., Selvan, R., Leiras, R. et al. Nat Neurosci (2023).

Clinicopathologic Dissociation: Robust Lafora Body Accumulation in Malin KO Mice Without Observable Changes in Home-cage Behavior. Vaishnav Krishnan et al. bioRxiv. 2023

Different Age Related Neurological and Cardiac Effects of Verapamil on a Transgenic Mouse Model of Alzheimer’s Disease. Alexandru Cojocaru et al. Curr Health Sci J. 2021

On the Mental Status of Stargazer Mice. Catharina Schirmer, et al. bioRxiv. 2022

Home-cage behavior in the Stargazer mutant mouse. Catharina Schirmer et al. Nature. 2022