Techniques & Measurements

This page lists techniques and measurements employed by
the rodentPACK system.

rodentPACK-telemetry setup

Wireless telemetry

rodentPACK removable transmitters are attached to a head connector or housed in a jacket during recording sessions, while physiological signals are radio-transmitted to a receiver within 3 to 5 meters distance.

Electroencephalogram

EEG acquisition is performed without the use of tethering cables.

A head connector is implanted in the skull and acts as an interface between the electrodes in the brain and the transmitter. The rodentPACK transmitter may be plugged into and removed from the head connector as required. In this way, the same transmitter is usable on any subject equipped with a connector.

With a transmitter battery powered and equipped with short leads length, rodentPACK provides a high signal-to-noise ratio and permits clean data collection.

The EEG signal is retrieved through surgically implanted electrodes in the cortex, the hippocampus or any other area of the brain. Each signal requires 2 measuring electrodes (positive and negative) and a reference, which is common to all biopotential signals.

Up to 4 bipolar biopotentials can be recorded with rodentPACK. Adjustable settings allow to mix EEG with ECG and/or intramuscular EMG.

Outcomes
  • Sleep scoring
  • Epileptic seizure detection
  • Spectral analysis

Did you know?

rodentPACK can be used for unipolar biopotential acquisition, on special request.

References

McGuire et al – Use of a Wireless Video-EEG System to Monitor Epileptiform Discharges Following Lateral Fluid-Percussion Induced Traumatic Brain Injury.  (2019).

JS Vuong. Head mounted telemetry system for seizures monitoring and sleep scoring on non-human primate. Journal of Neuroscience Methods vol 346 Aug 2020

ECG/EMG

Adjustable settings allow to mix EEG with ECG and/or intramuscular EMG.

For ECG acquisition, the transmitter can also be fixed to the skull connector (with implanted electrodes) or can be worn in a jacket (with external electrodes).

Outcomes

ECG signal: wave duration, amplitude, ST elevation, QT correction, arrythmia detection, HRV analysis.

EMG: Temporal and spectral analysis

Acceleration

A 3-axis accelerometer inside the rodentPACK transmitter measures the acceleration in the x-, y- and z-axis.

Any movement of the subject head translates in variations in the x, y, z coordinates of acceleration.

Using the three individual axis signals, IOX2 acquisition software calculates a global acceleration, making it possible to derive information about the animal’s posture (standing on hind legs, on its side etc).

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