Parkinson’s Disease
Parkinson’s Disease Parkinson’s disease (PD) is a neurodegenerative condition that primarily affects movement control. It occurs with neurodegeneration in the dopaminergic pathways of the brain, particularly in the basal ganglia and motor cortex. Researchers rely on various animal models to study Parkinson’s disease, which are essential for testing new treatments and understanding the progression of […]
Rett Syndrome
Rett Syndrome Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in the MECP2 gene, leading to various symptoms, including cognitive impairment, motor dysfunction, and significant respiratory abnormalities. The disease is hallmarked by repetitive movements and general developmental regression, however cause of death is often due epileptic or respiratory crises. Integrating vivoFlow plethysmography […]
Alzheimer’s Disease
Alzheimer’s Disease Alzheimer’s Disease is a progressive neurodegenerative disorder that primarily affects memory, cognition, and behavior. Key pathological features include the accumulation of amyloid plaques and tau tangles in the brain, which disrupt neural communication and cognitive functions. Understanding Alzheimer’s disease through preclinical studies is crucial for developing effective treatments. At emka TECHNOLOGIES, our digital […]
Addiction Research
Addiction Research Preclinical addiction research aim to uncover the complex interplay of brain mechanisms, genetic factors, and environmental influences that drive addiction. A range of preclinical animal models (rodents, non-human primates) are used to study addiction-like behaviors, such as drug self-administration, conditioned place preference, and withdrawal responses. These models help in simulating aspects of human […]
Fear & Extinction Learning Studies
Fear & Extinction Learning Studies Fear learning is a process where individuals associate a neutral stimulus (like a tone or light) with an aversive event (like a mild shock or unpleasant noise). This creates a fear response whenever the neutral stimulus is presented. Extinction learning happens when the fear-evoking stimulus is repeatedly presented without the […]
Control of breathing
Control of Breathing Respiration functions through a complex network of neural controls and feedback mechanisms as the body constantly adjusts its breathing rate and tidal volume to meet respiratory metabolic demands. Several diseases and conditions disrupt the neurological and muscular signals, compromising the body’s ability to breathe normally. Neurologic and muscular disorders like Duchenne muscular […]
Pulmonary hypertension
Pulmonary Hypertension Pulmonary hypertension (PH) is a condition characterized by elevated blood pressure in the arteries of the lungs, often leading to heart failure if left untreated. Preclinical research on PH involves various approaches to understand its pathophysiology and develop potential treatments. Animal models, particularly rodents and larger mammals, are commonly used to mimic PH […]
