Autonomic dysfunction
Autonomic dysfunction The Autonomic Nervous System, comprising the Sympathetic Nervous System (SNS) and Parasympathetic Nervous System (PNS), regulates essential physiological functions such as heart rate and blood pressure. These systems help control blood pressure through the baroreflex (or baroreceptor reflex) mechanism(1). The baroreflex is a homeostatic physiological mechanism that regulates blood pressure at constant levels. […]
Case study – A rat model of long-term deficit following severe traumatic brain injury
The ECG monitoring of exercise in Wistar rats following Traumatic Brain Injury offers insight into possible autonomic dysregulation. This case study highlights the ability to simultaneously record ECG in subjects exercising in an open pool.
Case study – A dual implantation for combined Neuro and Cardiovascular recording in dog.
Digital telemetry offers the ability to implant two transmitters in large animals, allowing to simultaneously record a large number of physiological parameters in a single subject. This case study highlights an experiment conducted by safety pharmacology team at Charles River Montreal, to combine seizure and cardiovascular liability assessment.
Behavioral studies
Behavioral studies The study of behavior is a major element of preclinical neuroscience research. Behavioral tests are used to characterize changes in brain function that may be produced by disease, neural injury, genetic modification, drug abuse and addiction, or exposure to various agents and treatments. Our close working relashionship with Noldus Information Technology, along with […]
Traumatic Brain Injury
Traumatic Brain Injury Traumatic Brain Injury (TBI) is defined as a damage to the brain resulting from an external mechanical force. TBI is a complex disease process (Masel BE & DeWitt DS, 2010) and several studies have demonstrated that long-term functional and structural changes take place up to one year after TBI (Smith DH et […]
Sleep disorders
Sleep disorders Preclinical sleep research is of increasing importance, not only due to the role of sleep in memory consolidation, but also because of the link that has been established between sleep disorders and some brain or cardiovascular disorders. Indeed, sleep disturbances are a common comorbidity with neurological and cardiovascular diseases. Narcolepsy, insomnia, circadian rhythm, drug […]
Seizure & epilepsy
Seizure & epilepsy Seizure is a disorder of the nervous system, thought to be the result of faulty electrical activity in the brain which can lead to changes in behavior, movement, feelings, and/or levels of consciousness. Epilepsy studies involve seizure detection from EEG traces, however other parameters can be of interest, such as ECG, EMG […]
Optogenetics
Optogenetics Optogenetics is a revolutionary biological technique that uses light to control and study neural pathways by activating light-sensitive proteins. This powerful method is widely applied in neuroscience to control real-time neuronal activity and investigate brain functions. Optogenetics holds significant promise in developing therapies for neurological disorders such as Parkinson’s disease, epilepsy, and depression, by […]
Parkinson’s Disease
Parkinson’s Disease Parkinson’s disease (PD) is a neurodegenerative condition that primarily affects movement control. It occurs with neurodegeneration in the dopaminergic pathways of the brain, particularly in the basal ganglia and motor cortex. Researchers rely on various animal models to study Parkinson’s disease, which are essential for testing new treatments and understanding the progression of […]
Rett Syndrome
Rett Syndrome Rett syndrome (RTT) is a severe neurodevelopmental disorder caused by mutations in the MECP2 gene, leading to various symptoms, including cognitive impairment, motor dysfunction, and significant respiratory abnormalities. The disease is hallmarked by repetitive movements and general developmental regression, however cause of death is often due epileptic or respiratory crises. Integrating vivoFlow plethysmography […]
